Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2931647..2932386 Replicon chromosome
Accession NZ_CP085774
Organism Enterobacter hormaechei strain 48947CZ

Toxin (Protein)


Gene name tacT Uniprot ID A0A822W909
Locus tag LJU36_RS14260 Protein ID WP_017382345.1
Coordinates 2931647..2932132 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag LJU36_RS14265 Protein ID WP_003857131.1
Coordinates 2932120..2932386 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU36_RS14235 (LJU36_14235) 2927233..2927817 - 585 WP_017382349.1 GDP-mannose pyrophosphatase nudK -
LJU36_RS14240 (LJU36_14240) 2927904..2928662 + 759 WP_023303741.1 DeoR/GlpR family DNA-binding transcription regulator -
LJU36_RS14245 (LJU36_14245) 2928767..2930059 + 1293 WP_023303742.1 glycosyl hydrolase family 28 protein -
LJU36_RS14250 (LJU36_14250) 2930059..2930673 + 615 WP_023303743.1 NUDIX hydrolase -
LJU36_RS14255 (LJU36_14255) 2931027..2931596 + 570 WP_017382346.1 hypothetical protein -
LJU36_RS14260 (LJU36_14260) 2931647..2932132 - 486 WP_017382345.1 GNAT family N-acetyltransferase Toxin
LJU36_RS14265 (LJU36_14265) 2932120..2932386 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
LJU36_RS14270 (LJU36_14270) 2932450..2933379 - 930 WP_023303744.1 LysR family transcriptional regulator -
LJU36_RS14275 (LJU36_14275) 2933509..2934897 + 1389 WP_032619651.1 MFS transporter -
LJU36_RS14280 (LJU36_14280) 2934919..2935914 - 996 WP_023303746.1 DUF2891 domain-containing protein -
LJU36_RS14285 (LJU36_14285) 2935924..2936910 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17510.21 Da        Isoelectric Point: 9.9658

>T221271 WP_017382345.1 NZ_CP085774:c2932132-2931647 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARAFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T221271 NZ_CP117370:206804-207289 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT221271 WP_003857131.1 NZ_CP085774:c2932386-2932120 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT221271 NZ_CP117370:206529-206816 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822W909

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References