Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1654481..1655101 Replicon chromosome
Accession NZ_CP085774
Organism Enterobacter hormaechei strain 48947CZ

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag LJU36_RS07900 Protein ID WP_015571250.1
Coordinates 1654481..1654699 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag LJU36_RS07905 Protein ID WP_006809850.1
Coordinates 1654727..1655101 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU36_RS07870 (LJU36_07870) 1650493..1650753 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
LJU36_RS07875 (LJU36_07875) 1650756..1650896 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LJU36_RS07880 (LJU36_07880) 1650893..1651603 - 711 WP_023303201.1 GNAT family protein -
LJU36_RS07885 (LJU36_07885) 1651705..1653165 + 1461 WP_023303202.1 PLP-dependent aminotransferase family protein -
LJU36_RS07890 (LJU36_07890) 1653137..1653604 - 468 WP_017383209.1 YlaC family protein -
LJU36_RS07895 (LJU36_07895) 1653721..1654272 - 552 WP_023303203.1 maltose O-acetyltransferase -
LJU36_RS07900 (LJU36_07900) 1654481..1654699 - 219 WP_015571250.1 HHA domain-containing protein Toxin
LJU36_RS07905 (LJU36_07905) 1654727..1655101 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
LJU36_RS07910 (LJU36_07910) 1655612..1658758 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
LJU36_RS07915 (LJU36_07915) 1658781..1659974 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T221270 WP_015571250.1 NZ_CP085774:c1654699-1654481 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T221270 NZ_CP117369:39670-39951 [Salmonella enterica subsp. enterica serovar Dublin]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT221270 WP_006809850.1 NZ_CP085774:c1655101-1654727 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT221270 NZ_CP117369:39429-39680 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References