Detailed information of TA system TA221254

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 3533116..3534029
• Replicon: chromosome
• Accession: NZ_CP085767
• Organism: Enterobacter hormaechei strain 49589CZ

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LJU37_RS16750
• Protein ID: WP_047052345.1
• Coordinates: 3533116..3533589 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LJU37_RS16755
• Protein ID: WP_047052347.1
• Coordinates: 3533586..3534029 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJU37_RS16730 (LJU37_16730)	3529275..3530585	+	1311	WP_047052339.1	type I-F CRISPR-associated protein Csy1	-
LJU37_RS16735 (LJU37_16735)	3530582..3531517	+	936	WP_047052340.1	type I-F CRISPR-associated protein Csy2	-
LJU37_RS16740 (LJU37_16740)	3531531..3532529	+	999	WP_047052342.1	type I-F CRISPR-associated protein Csy3	-
LJU37_RS16745 (LJU37_16745)	3532539..3533093	+	555	WP_047052344.1	type I-F CRISPR-associated endoribonuclease Cas6/Csy4	-
LJU37_RS16750 (LJU37_16750)	3533116..3533589	-	474	WP_047052345.1	RES domain-containing protein	Toxin
LJU37_RS16755 (LJU37_16755)	3533586..3534029	-	444	WP_047052347.1	DUF2384 domain-containing protein	Antitoxin
LJU37_RS16760 (LJU37_16760)	3535981..3536199	-	219	WP_002211347.1	translation initiation factor IF-1	-
LJU37_RS16765 (LJU37_16765)	3536484..3537188	-	705	WP_047052381.1	leucyl/phenylalanyl-tRNA--protein transferase	-
LJU37_RS16770 (LJU37_16770)	3537234..3538955	-	1722	WP_003858307.1	cysteine/glutathione ABC transporter ATP-binding protein/permease CydC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-144)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17570.95 Da
• Isoelectric Point: 5.1151

>T221254 WP_047052345.1 NZ_CP085767:c3533589-3533116 [Enterobacter hormaechei]
MIFYRLVTGRFASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHVRKDTVLNQYQLFSINIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQANSALALILPSCIIPYENNAILNPLHPAFRKALNSVELLPFDFDTRLAEKTAP

Nucleotide

• Length: 474 bp

>T221254 NZ_CP117367:861779-862192 [Salmonella enterica subsp. enterica serovar Dublin]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGTCAACACTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16502.77 Da
• Isoelectric Point: 6.4819

>AT221254 WP_047052347.1 NZ_CP085767:c3534029-3533586 [Enterobacter hormaechei]
MRTWVPAQRSADNTLWRYAGLPASRGMRLIEYLNQGLPVSVLDNIHEWTDMSKAEILRVTGINERNVARRKSTGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQLPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT221254 NZ_CP117367:861532-861798 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA