Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 2939215..2939924 | Replicon | chromosome |
| Accession | NZ_CP085767 | ||
| Organism | Enterobacter hormaechei strain 49589CZ | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | A0A7D6YAQ1 |
| Locus tag | LJU37_RS13965 | Protein ID | WP_071886833.1 |
| Coordinates | 2939556..2939924 (+) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | - |
| Locus tag | LJU37_RS13960 | Protein ID | WP_047051179.1 |
| Coordinates | 2939215..2939535 (+) | Length | 107 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJU37_RS13915 (LJU37_13915) | 2934449..2934679 | + | 231 | Protein_2688 | hypothetical protein | - |
| LJU37_RS13920 (LJU37_13920) | 2934775..2935609 | + | 835 | Protein_2689 | DUF932 domain-containing protein | - |
| LJU37_RS13925 (LJU37_13925) | 2935811..2936515 | + | 705 | WP_047051185.1 | WYL domain-containing protein | - |
| LJU37_RS13930 (LJU37_13930) | 2936512..2937126 | + | 615 | WP_047051184.1 | hypothetical protein | - |
| LJU37_RS13935 (LJU37_13935) | 2937215..2937625 | + | 411 | WP_047051183.1 | hypothetical protein | - |
| LJU37_RS13940 (LJU37_13940) | 2937702..2937938 | + | 237 | WP_047051182.1 | DUF905 domain-containing protein | - |
| LJU37_RS13945 (LJU37_13945) | 2938018..2938476 | + | 459 | WP_047051181.1 | antirestriction protein | - |
| LJU37_RS13950 (LJU37_13950) | 2938485..2938967 | + | 483 | WP_075211782.1 | DNA repair protein RadC | - |
| LJU37_RS13955 (LJU37_13955) | 2938976..2939197 | + | 222 | WP_016243789.1 | DUF987 domain-containing protein | - |
| LJU37_RS13960 (LJU37_13960) | 2939215..2939535 | + | 321 | WP_047051179.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LJU37_RS13965 (LJU37_13965) | 2939556..2939924 | + | 369 | WP_071886833.1 | TA system toxin CbtA family protein | Toxin |
| LJU37_RS13970 (LJU37_13970) | 2940270..2941016 | - | 747 | WP_047051178.1 | class I SAM-dependent methyltransferase | - |
| LJU37_RS13975 (LJU37_13975) | 2941027..2941284 | - | 258 | WP_003863178.1 | YjhX family toxin | - |
| LJU37_RS13980 (LJU37_13980) | 2941544..2941921 | - | 378 | Protein_2701 | EAL domain-containing protein | - |
| LJU37_RS13985 (LJU37_13985) | 2941971..2942939 | - | 969 | WP_022649395.1 | IS5-like element IS903B family transposase | - |
| LJU37_RS13990 (LJU37_13990) | 2942973..2944547 | - | 1575 | Protein_2703 | diguanylate cyclase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2931320..2945059 | 13739 | |
| - | flank | IS/Tn | - | - | 2941971..2942939 | 968 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13738.90 Da Isoelectric Point: 8.1347
>T221252 WP_071886833.1 NZ_CP085767:2939556-2939924 [Enterobacter hormaechei]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDQTVIQEHIDAGITLANAVNFLVEKYELVRIDRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSRQ
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDQTVIQEHIDAGITLANAVNFLVEKYELVRIDRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSRQ
Download Length: 369 bp
>T221252 NZ_CP117367:308505-308873 [Salmonella enterica subsp. enterica serovar Dublin]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGAGCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGAGCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA
Antitoxin
Download Length: 107 a.a. Molecular weight: 11901.60 Da Isoelectric Point: 7.2633
>AT221252 WP_047051179.1 NZ_CP085767:2939215-2939535 [Enterobacter hormaechei]
MRSNATWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFISLMESMLTTGEMNPRHAHCVTLY
RNGFTCEADTLGSCGYLYIVVYPTQS
MRSNATWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFISLMESMLTTGEMNPRHAHCVTLY
RNGFTCEADTLGSCGYLYIVVYPTQS
Download Length: 321 bp
>AT221252 NZ_CP117367:308287-308508 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|