Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 114685..115424 Replicon plasmid p54569CZ_VIM
Accession NZ_CP085763
Organism Enterobacter hormaechei strain 54569CZ

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag LJU41_RS23020 Protein ID WP_013087269.1
Coordinates 114939..115424 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag LJU41_RS23015 Protein ID WP_007869691.1
Coordinates 114685..114951 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU41_RS22990 (LJU41_22990) 109751..110521 + 771 WP_013087103.1 TraX family protein -
LJU41_RS22995 (LJU41_22995) 110536..110874 + 339 WP_013087102.1 hypothetical protein -
LJU41_RS23000 (LJU41_23000) 110957..111286 + 330 WP_013087101.1 hypothetical protein -
LJU41_RS23005 (LJU41_23005) 111261..112067 - 807 WP_013087100.1 DUF4225 domain-containing protein -
LJU41_RS23010 (LJU41_23010) 113018..114031 - 1014 WP_013087098.1 plasmid replication initiator RepA -
LJU41_RS23015 (LJU41_23015) 114685..114951 + 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
LJU41_RS23020 (LJU41_23020) 114939..115424 + 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
LJU41_RS23025 (LJU41_23025) 115791..116609 - 819 WP_013087268.1 abortive infection family protein -
LJU41_RS23035 (LJU41_23035) 117358..118188 - 831 WP_100135202.1 hypothetical protein -
LJU41_RS23040 (LJU41_23040) 118322..118960 - 639 WP_008786709.1 DUF2913 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / qacE / ant(3'')-Ia / blaVIM-1 / aac(6')-Ib-cr / blaOXA-1 / aac(3)-IIa / dfrA14 / qnrB56 - 1..171616 171616


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T221242 WP_013087269.1 NZ_CP085763:114939-115424 [Enterobacter hormaechei]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T221242 NZ_CP117365:836497-836895 [Salmonella enterica subsp. enterica serovar Newport]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT221242 WP_007869691.1 NZ_CP085763:114685-114951 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT221242 NZ_CP117365:836270-836497 [Salmonella enterica subsp. enterica serovar Newport]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGATGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References