Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 81260..81897 Replicon plasmid p54569CZ_VIM
Accession NZ_CP085763
Organism Enterobacter hormaechei strain 54569CZ

Toxin (Protein)


Gene name vagD Uniprot ID A0A9E6WXZ4
Locus tag LJU41_RS22855 Protein ID WP_032662169.1
Coordinates 81487..81897 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A9E6WTF5
Locus tag LJU41_RS22850 Protein ID WP_032662167.1
Coordinates 81260..81490 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU41_RS22825 (LJU41_22825) 77259..78269 + 1011 WP_015572055.1 RepB family plasmid replication initiator protein -
LJU41_RS22830 (LJU41_22830) 78513..78770 - 258 Protein_99 site-specific integrase -
LJU41_RS22835 (LJU41_22835) 78972..79748 - 777 WP_015572054.1 site-specific integrase -
LJU41_RS22840 (LJU41_22840) 79767..80297 - 531 WP_013087127.1 hypothetical protein -
LJU41_RS22845 (LJU41_22845) 80428..80718 - 291 WP_013087126.1 hypothetical protein -
LJU41_RS22850 (LJU41_22850) 81260..81490 + 231 WP_032662167.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LJU41_RS22855 (LJU41_22855) 81487..81897 + 411 WP_032662169.1 PIN domain-containing protein Toxin
LJU41_RS22860 (LJU41_22860) 81971..83533 + 1563 WP_032662171.1 AAA family ATPase -
LJU41_RS22865 (LJU41_22865) 83518..84540 + 1023 WP_032662174.1 helicase UvrD -
LJU41_RS22870 (LJU41_22870) 85087..85995 + 909 WP_032662179.1 HNH endonuclease -
LJU41_RS22875 (LJU41_22875) 86181..86531 - 351 WP_032662182.1 DUF305 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / qacE / ant(3'')-Ia / blaVIM-1 / aac(6')-Ib-cr / blaOXA-1 / aac(3)-IIa / dfrA14 / qnrB56 - 1..171616 171616


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-127)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14729.03 Da        Isoelectric Point: 5.7351

>T221241 WP_032662169.1 NZ_CP085763:81487-81897 [Enterobacter hormaechei]
VNKMYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITWAEVSLASQEAGPAAQKLADAFAARLDAILPWDRTAV
DATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVR

Download         Length: 411 bp

>T221241 NZ_CP117365:825630-826043 [Salmonella enterica subsp. enterica serovar Newport]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8645.77 Da        Isoelectric Point: 4.4692

>AT221241 WP_032662167.1 NZ_CP085763:81260-81490 [Enterobacter hormaechei]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMAERGDVVSDEGRVNL

Download         Length: 231 bp

>AT221241 NZ_CP117365:825383-825649 [Salmonella enterica subsp. enterica serovar Newport]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAATTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References