Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 29312..29838 Replicon plasmid p54569CZ_VIM
Accession NZ_CP085763
Organism Enterobacter hormaechei strain 54569CZ

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag LJU41_RS22495 Protein ID WP_000323025.1
Coordinates 29312..29599 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag LJU41_RS22500 Protein ID WP_004196370.1
Coordinates 29599..29838 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU41_RS22460 (LJU41_22460) 24831..25454 - 624 Protein_26 conjugative transfer relaxase/helicase TraI -
LJU41_RS22465 (LJU41_22465) 25981..26181 - 201 WP_013087182.1 hypothetical protein -
LJU41_RS22470 (LJU41_22470) 26269..26730 - 462 WP_013087181.1 hypothetical protein -
LJU41_RS22475 (LJU41_22475) 26791..27105 - 315 WP_044157807.1 hypothetical protein -
LJU41_RS22480 (LJU41_22480) 27985..28095 - 111 WP_230678187.1 DUF5431 family protein -
LJU41_RS22490 (LJU41_22490) 28211..29245 + 1035 Protein_31 IS481 family transposase -
LJU41_RS22495 (LJU41_22495) 29312..29599 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
LJU41_RS22500 (LJU41_22500) 29599..29838 - 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
LJU41_RS22505 (LJU41_22505) 29863..29961 + 99 Protein_34 protein YdfV -
LJU41_RS22510 (LJU41_22510) 30158..31278 + 1121 WP_087451024.1 IS3-like element ISSen4 family transposase -
LJU41_RS22515 (LJU41_22515) 31314..31679 + 366 WP_009651956.1 hypothetical protein -
LJU41_RS22520 (LJU41_22520) 31723..32460 + 738 WP_008460272.1 HupE/UreJ family protein -
LJU41_RS22525 (LJU41_22525) 32474..33163 + 690 WP_013087175.1 hypothetical protein -
LJU41_RS22530 (LJU41_22530) 33194..34570 - 1377 WP_004196363.1 chromate efflux transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / qacE / ant(3'')-Ia / blaVIM-1 / aac(6')-Ib-cr / blaOXA-1 / aac(3)-IIa / dfrA14 / qnrB56 - 1..171616 171616
- inside IScluster/Tn sul1 / qacE / ant(3'')-Ia / blaVIM-1 - 375..31278 30903


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T221239 WP_000323025.1 NZ_CP085763:c29599-29312 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T221239 NZ_CP117364:41984-42265 [Salmonella enterica subsp. enterica serovar Dublin]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT221239 WP_004196370.1 NZ_CP085763:c29838-29599 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT221239 NZ_CP117364:41743-41994 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References