Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3927547..3928167 Replicon chromosome
Accession NZ_CP085757
Organism Enterobacter hormaechei strain 54569CZ

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag LJU41_RS18885 Protein ID WP_015571250.1
Coordinates 3927547..3927765 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag LJU41_RS18890 Protein ID WP_006809850.1
Coordinates 3927793..3928167 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU41_RS18855 (LJU41_18855) 3923559..3923819 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
LJU41_RS18860 (LJU41_18860) 3923822..3923962 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LJU41_RS18865 (LJU41_18865) 3923959..3924669 - 711 WP_022650493.1 GNAT family protein -
LJU41_RS18870 (LJU41_18870) 3924771..3926231 + 1461 WP_060579813.1 PLP-dependent aminotransferase family protein -
LJU41_RS18875 (LJU41_18875) 3926203..3926670 - 468 WP_022650495.1 YlaC family protein -
LJU41_RS18880 (LJU41_18880) 3926787..3927338 - 552 WP_022650496.1 maltose O-acetyltransferase -
LJU41_RS18885 (LJU41_18885) 3927547..3927765 - 219 WP_015571250.1 HHA domain-containing protein Toxin
LJU41_RS18890 (LJU41_18890) 3927793..3928167 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
LJU41_RS18895 (LJU41_18895) 3928678..3931824 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit AcrB -
LJU41_RS18900 (LJU41_18900) 3931847..3933040 - 1194 WP_022650498.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T221238 WP_015571250.1 NZ_CP085757:c3927765-3927547 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T221238 NZ_CP117364:13420-13725 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT221238 WP_006809850.1 NZ_CP085757:c3928167-3927793 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT221238 NZ_CP117364:13200-13418 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References