Detailed information of TA system TA221237

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 3185328..3185924
• Replicon: chromosome
• Accession: NZ_CP085757
• Organism: Enterobacter hormaechei strain 54569CZ

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A837F9W8
• Locus tag: LJU41_RS15370
• Protein ID: WP_023315213.1
• Coordinates: 3185622..3185924 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: LJU41_RS15365
• Protein ID: WP_023315212.1
• Coordinates: 3185328..3185615 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJU41_RS15360 (LJU41_15360)	3183700..3185331	+	1632	WP_003860350.1	Na/Pi cotransporter family protein	-
LJU41_RS15365 (LJU41_15365)	3185328..3185615	-	288	WP_023315212.1	putative addiction module antidote protein	Antitoxin
LJU41_RS15370 (LJU41_15370)	3185622..3185924	-	303	WP_023315213.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LJU41_RS15375 (LJU41_15375)	3186122..3186994	+	873	WP_022646725.1	23S rRNA pseudouridine(2604) synthase RluF	-
LJU41_RS15380 (LJU41_15380)	3186995..3187267	-	273	WP_060580348.1	DUF3811 domain-containing protein	-
LJU41_RS15385 (LJU41_15385)	3187318..3188262	-	945	WP_022650218.1	ketopantoate/pantoate/pantothenate transporter PanS	-
LJU41_RS15390 (LJU41_15390)	3188356..3189705	-	1350	WP_003860344.1	lysine-sensitive aspartokinase 3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-93)

Antitoxin

• Uncharacterized protein HI1420 (3-90)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11427.21 Da
• Isoelectric Point: 10.1042

>T221237 WP_023315213.1 NZ_CP085757:c3185924-3185622 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRVYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Nucleotide

• Length: 303 bp

>T221237 NZ_CP117364:c12228-11800 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAAACAGCCACGTACGAAGACCTATATGCTCGATACCTGTATCTGTTCGTTCATCATGCGCGAGCAGTCGGAAGCGGT
GCTGAAGCGCCTTGAGCAGGCGGTGCTGCGCGGCCACCGTATCGTGATCTCGGCCATCACCTACTCCGAGATGCGCTTCG
GCGCCACCGGACCTAAGGCCTCGCCGCGTCTCGTCCAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCC
TGGGATCGCGCTGCGGTAGACGCCACCACGGAGATTAAGGTGGCACTGTGCCTCGCCGGGACGCCGATCGGTCCGAACGA
CACGGCGATTGCCGGGCATGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGG
GCCTGGTACTGGAAGACTGGGTAAGTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10171.73 Da
• Isoelectric Point: 7.0086

>AT221237 WP_023315212.1 NZ_CP085757:c3185615-3185328 [Enterobacter hormaechei]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISLQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLRLTIKPSGD

Nucleotide

• Length: 288 bp

>AT221237 NZ_CP117364:c12455-12225 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAGAACCGTATCCATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGCTTTGAGCTATGA

Structures

Toxin

• AlphaFold DB: A0A837F9W8