Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1985627..1986284 Replicon chromosome
Accession NZ_CP085757
Organism Enterobacter hormaechei strain 54569CZ

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag LJU41_RS09565 Protein ID WP_022649305.1
Coordinates 1985627..1986037 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LJU41_RS09570 Protein ID WP_003863437.1
Coordinates 1986018..1986284 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU41_RS09545 (LJU41_09545) 1981625..1983358 - 1734 WP_058658593.1 single-stranded-DNA-specific exonuclease RecJ -
LJU41_RS09550 (LJU41_09550) 1983364..1984077 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJU41_RS09555 (LJU41_09555) 1984106..1985002 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
LJU41_RS09560 (LJU41_09560) 1985104..1985625 + 522 WP_003863440.1 flavodoxin FldB -
LJU41_RS09565 (LJU41_09565) 1985627..1986037 - 411 WP_022649305.1 protein YgfX Toxin
LJU41_RS09570 (LJU41_09570) 1986018..1986284 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LJU41_RS09575 (LJU41_09575) 1986579..1987559 + 981 WP_023314796.1 tRNA-modifying protein YgfZ -
LJU41_RS09580 (LJU41_09580) 1987645..1988304 - 660 WP_023314797.1 hemolysin III family protein -
LJU41_RS09585 (LJU41_09585) 1988571..1989302 + 732 WP_023314798.1 MurR/RpiR family transcriptional regulator -
LJU41_RS09590 (LJU41_09590) 1989419..1990852 + 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T221235 WP_022649305.1 NZ_CP085757:c1986037-1985627 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T221235 NZ_CP117362:4654716-4655027 [Salmonella enterica subsp. enterica serovar Dublin]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGATCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT221235 WP_003863437.1 NZ_CP085757:c1986284-1986018 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT221235 NZ_CP117362:4655024-4655470 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAATCACTCAAC
CAACACCTGGAGAAAACACCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATCAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References