Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 1327701..1329484 Replicon chromosome
Accession NZ_CP085757
Organism Enterobacter hormaechei strain 54569CZ

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LJU41_RS06545 Protein ID WP_060580136.1
Coordinates 1327701..1329050 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A837FFV9
Locus tag LJU41_RS06550 Protein ID WP_003859317.1
Coordinates 1329047..1329484 (+) Length 146 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU41_RS06520 (LJU41_06520) 1323524..1324459 - 936 WP_060580134.1 tRNA dihydrouridine(16) synthase DusC -
LJU41_RS06525 (LJU41_06525) 1324628..1325023 + 396 WP_060580135.1 CidA/LrgA family protein -
LJU41_RS06530 (LJU41_06530) 1325020..1325715 + 696 WP_003859310.1 CidB/LrgB family autolysis modulator -
LJU41_RS06535 (LJU41_06535) 1325844..1326728 + 885 WP_003859312.1 cytidine deaminase -
LJU41_RS06540 (LJU41_06540) 1326856..1327566 + 711 WP_003859314.1 outer membrane permeability protein SanA -
LJU41_RS06545 (LJU41_06545) 1327701..1329050 + 1350 WP_060580136.1 HipA domain-containing protein Toxin
LJU41_RS06550 (LJU41_06550) 1329047..1329484 + 438 WP_003859317.1 helix-turn-helix transcriptional regulator Antitoxin
LJU41_RS06555 (LJU41_06555) 1329523..1330533 - 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
LJU41_RS06560 (LJU41_06560) 1330549..1332069 - 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
LJU41_RS06565 (LJU41_06565) 1332149..1333147 - 999 WP_017383382.1 galactose/glucose ABC transporter substrate-binding protein MglB -
LJU41_RS06570 (LJU41_06570) 1333443..1334465 - 1023 WP_003859324.1 HTH-type transcriptional regulator GalS -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(166-406)

Antitoxin

(75-128)


Sequences


Toxin        


Download         Length: 450 a.a.        Molecular weight: 51150.87 Da        Isoelectric Point: 4.6112

>T221233 WP_060580136.1 NZ_CP085757:1327701-1329050 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNITQLDYLTEYAINFLDYDDFHAVPVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Download         Length: 1350 bp

>T221233 NZ_CP117362:c4344339-4343848 [Salmonella enterica subsp. enterica serovar Dublin]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAGCGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAAGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16185.64 Da        Isoelectric Point: 10.5154

>AT221233 WP_003859317.1 NZ_CP085757:1329047-1329484 [Enterobacter hormaechei]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp

>AT221233 NZ_CP117362:c4344629-4344336 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCCGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCCTATCAGGAATTTCTGGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A837FFV9

References