Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 203734..204260 Replicon plasmid p57816CZ_MCR_9
Accession NZ_CP085755
Organism Enterobacter hormaechei strain 57816CZ

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag LJU43_RS25415 Protein ID WP_000323025.1
Coordinates 203734..204021 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag LJU43_RS25420 Protein ID WP_000534858.1
Coordinates 204021..204260 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU43_RS25380 (LJU43_25380) 199304..199480 - 177 WP_001371930.1 hypothetical protein -
LJU43_RS25385 (LJU43_25385) 199991..200935 + 945 WP_000778029.1 DUF5417 domain-containing protein -
LJU43_RS25390 (LJU43_25390) 201031..201633 + 603 WP_012695474.1 hypothetical protein -
LJU43_RS25395 (LJU43_25395) 201693..202043 + 351 WP_000743059.1 hypothetical protein -
LJU43_RS25400 (LJU43_25400) 202575..202895 + 321 WP_000332796.1 hypothetical protein -
LJU43_RS25405 (LJU43_25405) 203508..203633 - 126 WP_229020258.1 DUF5431 family protein -
LJU43_RS25415 (LJU43_25415) 203734..204021 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
LJU43_RS25420 (LJU43_25420) 204021..204260 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
LJU43_RS25425 (LJU43_25425) 204285..204389 + 105 Protein_212 protein YdfV -
LJU43_RS25430 (LJU43_25430) 204523..205446 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
LJU43_RS25435 (LJU43_25435) 205646..206218 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
LJU43_RS25440 (LJU43_25440) 206694..207932 - 1239 WP_000219087.1 IS110-like element ISEsa2 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / catA2 / aadA2 / qacE / sul1 / dfrA19 / aph(3'')-Ib / aph(6)-Id / mcr-9 / tet(D) / aac(6')-IIc / ere(A) / sul2 / blaSHV-12 - 1..289297 289297


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T221223 WP_000323025.1 NZ_CP085755:c204021-203734 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T221223 NZ_CP117362:358257-358532 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT221223 WP_000534858.1 NZ_CP085755:c204260-204021 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT221223 NZ_CP117362:357994-358254 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References