Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2915290..2915947 Replicon chromosome
Accession NZ_CP085753
Organism Enterobacter hormaechei strain 57816CZ

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag LJU43_RS14115 Protein ID WP_017382887.1
Coordinates 2915537..2915947 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LJU43_RS14110 Protein ID WP_003863437.1
Coordinates 2915290..2915556 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU43_RS14090 (2910696) 2910696..2912129 - 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -
LJU43_RS14095 (2912246) 2912246..2912977 - 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
LJU43_RS14100 (2913244) 2913244..2913903 + 660 WP_003863433.1 hemolysin III family protein -
LJU43_RS14105 (2914015) 2914015..2914995 - 981 WP_017382888.1 tRNA-modifying protein YgfZ -
LJU43_RS14110 (2915290) 2915290..2915556 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LJU43_RS14115 (2915537) 2915537..2915947 + 411 WP_017382887.1 protein YgfX Toxin
LJU43_RS14120 (2915949) 2915949..2916470 - 522 WP_015571793.1 flavodoxin FldB -
LJU43_RS14125 (2916572) 2916572..2917468 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
LJU43_RS14130 (2917497) 2917497..2918210 + 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJU43_RS14135 (2918216) 2918216..2919949 + 1734 WP_045141946.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T221210 WP_017382887.1 NZ_CP085753:2915537-2915947 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T221210 NZ_CP117359:3736657-3736914 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT221210 WP_003863437.1 NZ_CP085753:2915290-2915556 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT221210 NZ_CP117359:c3736832-3736500 [Salmonella enterica subsp. enterica serovar Dublin]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References