Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1889005..1889744 Replicon chromosome
Accession NZ_CP085753
Organism Enterobacter hormaechei strain 57816CZ

Toxin (Protein)


Gene name tacT Uniprot ID A0A5E1AVR5
Locus tag LJU43_RS09230 Protein ID WP_013087172.1
Coordinates 1889259..1889744 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A5E1AWX8
Locus tag LJU43_RS09225 Protein ID WP_012540086.1
Coordinates 1889005..1889271 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU43_RS09195 (1884236) 1884236..1884772 - 537 WP_013087166.1 GNAT family N-acetyltransferase -
LJU43_RS09200 (1884897) 1884897..1886654 - 1758 WP_013087167.1 arsenical pump-driving ATPase -
LJU43_RS09205 (1886675) 1886675..1887037 - 363 WP_013087168.1 arsenic metallochaperone ArsD family protein -
LJU43_RS09210 (1887113) 1887113..1887658 - 546 WP_013087169.1 sigma-70 family RNA polymerase sigma factor -
LJU43_RS09215 (1887667) 1887667..1888380 - 714 Protein_1789 arsenical resistance protein ArsH -
LJU43_RS09220 (1888382) 1888382..1888705 - 324 WP_013087171.1 metalloregulator ArsR/SmtB family transcription factor -
LJU43_RS09225 (1889005) 1889005..1889271 + 267 WP_012540086.1 DUF1778 domain-containing protein Antitoxin
LJU43_RS09230 (1889259) 1889259..1889744 + 486 WP_013087172.1 GNAT family N-acetyltransferase Toxin
LJU43_RS09235 (1890162) 1890162..1890488 + 327 Protein_1793 helix-turn-helix domain-containing protein -
LJU43_RS09240 (1890532) 1890532..1891236 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
LJU43_RS09245 (1892110) 1892110..1892397 - 288 WP_009486461.1 thermonuclease family protein -
LJU43_RS26305 (1892451) 1892451..1892579 - 129 Protein_1796 DNA polymerase V subunit UmuC -
LJU43_RS09250 (1892690) 1892690..1893126 + 437 Protein_1797 transposase -
LJU43_RS09255 (1893316) 1893316..1893690 + 375 WP_001348195.1 cupin domain-containing protein -
LJU43_RS09260 (1893714) 1893714..1894277 + 564 WP_001097412.1 chlorite dismutase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17810.62 Da        Isoelectric Point: 9.8560

>T221208 WP_013087172.1 NZ_CP085753:1889259-1889744 [Enterobacter hormaechei]
VGRVTVPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLKLP
Q

Download         Length: 486 bp

>T221208 NZ_CP117359:c2725754-2725651 [Salmonella enterica subsp. enterica serovar Dublin]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10076.47 Da        Isoelectric Point: 4.3721

>AT221208 WP_012540086.1 NZ_CP085753:1889005-1889271 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT221208 NZ_CP117359:2725649-2725794 [Salmonella enterica subsp. enterica serovar Dublin]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AVR5

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AWX8

References