Detailed information of TA system TA221206

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 1581370..1581966
• Replicon: chromosome
• Accession: NZ_CP085753
• Organism: Enterobacter hormaechei strain 57816CZ

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A7G3EX93
• Locus tag: LJU43_RS07665
• Protein ID: WP_015570164.1
• Coordinates: 1581370..1581672 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: A0A927HL08
• Locus tag: LJU43_RS07670
• Protein ID: WP_023295755.1
• Coordinates: 1581679..1581966 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJU43_RS07645 (1577589)	1577589..1578938	+	1350	WP_006810501.1	lysine-sensitive aspartokinase 3	-
LJU43_RS07650 (1579032)	1579032..1579976	+	945	WP_015570166.1	ketopantoate/pantoate/pantothenate transporter PanS	-
LJU43_RS07655 (1580027)	1580027..1580299	+	273	WP_017382612.1	DUF3811 domain-containing protein	-
LJU43_RS07660 (1580300)	1580300..1581172	-	873	WP_003860347.1	23S rRNA pseudouridine(2604) synthase RluF	-
LJU43_RS07665 (1581370)	1581370..1581672	+	303	WP_015570164.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LJU43_RS07670 (1581679)	1581679..1581966	+	288	WP_023295755.1	putative addiction module antidote protein	Antitoxin
LJU43_RS07675 (1581963)	1581963..1583594	-	1632	WP_003860350.1	Na/Pi cotransporter family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-93)

Antitoxin

• Uncharacterized protein HI1420 (3-90)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11425.18 Da
• Isoelectric Point: 10.3736

>T221206 WP_015570164.1 NZ_CP085753:1581370-1581672 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRIYFKDQGNSIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Nucleotide

• Length: 303 bp

>T221206 NZ_CP117359:835443-835841 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10101.59 Da
• Isoelectric Point: 5.7807

>AT221206 WP_023295755.1 NZ_CP085753:1581679-1581966 [Enterobacter hormaechei]
MHKLTPYDPANALLDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Nucleotide

• Length: 288 bp

>AT221206 NZ_CP117359:835216-835443 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Structures

Toxin

• AlphaFold DB: A0A7G3EX93