Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 797252..797872 Replicon chromosome
Accession NZ_CP085753
Organism Enterobacter hormaechei strain 57816CZ

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag LJU43_RS03960 Protein ID WP_015571250.1
Coordinates 797654..797872 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag LJU43_RS03955 Protein ID WP_006809850.1
Coordinates 797252..797626 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU43_RS03945 (792379) 792379..793572 + 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LJU43_RS03950 (793595) 793595..796741 + 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
LJU43_RS03955 (797252) 797252..797626 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
LJU43_RS03960 (797654) 797654..797872 + 219 WP_015571250.1 HHA domain-containing protein Toxin
LJU43_RS03965 (798081) 798081..798632 + 552 WP_015571251.1 maltose O-acetyltransferase -
LJU43_RS03970 (798749) 798749..799216 + 468 WP_015571252.1 YlaC family protein -
LJU43_RS03975 (799188) 799188..800648 - 1461 WP_045142063.1 PLP-dependent aminotransferase family protein -
LJU43_RS03980 (800750) 800750..801460 + 711 WP_181494061.1 GNAT family protein -
LJU43_RS03985 (801457) 801457..801597 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LJU43_RS03990 (801600) 801600..801860 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T221205 WP_015571250.1 NZ_CP085753:797654-797872 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T221205 NZ_CP117359:824539-824952 [Salmonella enterica subsp. enterica serovar Dublin]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGTCAACACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT221205 WP_006809850.1 NZ_CP085753:797252-797626 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT221205 NZ_CP117359:824292-824558 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References