Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | kacAT/DUF1778(antitoxin) |
| Location | 155650..156447 | Replicon | chromosome |
| Accession | NZ_CP085753 | ||
| Organism | Enterobacter hormaechei strain 57816CZ | ||
Toxin (Protein)
| Gene name | KacT | Uniprot ID | - |
| Locus tag | LJU43_RS00855 | Protein ID | WP_045141441.1 |
| Coordinates | 155650..156171 (-) | Length | 174 a.a. |
Antitoxin (Protein)
| Gene name | KacA | Uniprot ID | F5RT92 |
| Locus tag | LJU43_RS00860 | Protein ID | WP_001303459.1 |
| Coordinates | 156178..156447 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJU43_RS00825 (151248) | 151248..151937 | + | 690 | WP_045141445.1 | pyrimidine utilization protein B | - |
| LJU43_RS00830 (151949) | 151949..152335 | + | 387 | WP_015570870.1 | pyrimidine utilization protein C | - |
| LJU43_RS00835 (152343) | 152343..153143 | + | 801 | WP_039271149.1 | pyrimidine utilization protein D | - |
| LJU43_RS00840 (153153) | 153153..153743 | + | 591 | WP_062934089.1 | malonic semialdehyde reductase | - |
| LJU43_RS00845 (153756) | 153756..154247 | + | 492 | WP_045141443.1 | pyrimidine utilization flavin reductase protein F | - |
| LJU43_RS00850 (154269) | 154269..155591 | + | 1323 | WP_045141442.1 | pyrimidine utilization transport protein G | - |
| LJU43_RS00855 (155650) | 155650..156171 | - | 522 | WP_045141441.1 | GNAT family N-acetyltransferase | Toxin |
| LJU43_RS00860 (156178) | 156178..156447 | - | 270 | WP_001303459.1 | DUF1778 domain-containing protein | Antitoxin |
| LJU43_RS00865 (156521) | 156521..157426 | - | 906 | WP_045141440.1 | DMT family transporter | - |
| LJU43_RS00870 (157543) | 157543..157713 | - | 171 | WP_001273664.1 | general stress protein | - |
| LJU43_RS00875 (158105) | 158105..158701 | + | 597 | WP_006809323.1 | NAD(P)H:quinone oxidoreductase | - |
| LJU43_RS00880 (158720) | 158720..158947 | + | 228 | WP_006809324.1 | YccJ family protein | - |
| LJU43_RS00885 (158980) | 158980..160221 | - | 1242 | WP_017693667.1 | bifunctional glucose-1-phosphatase/inositol phosphatase | - |
| LJU43_RS00890 (160374) | 160374..160469 | + | 96 | Protein_176 | transcriptional regulator | - |
| LJU43_RS00895 (160548) | 160548..160907 | - | 360 | WP_017384779.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 174 a.a. Molecular weight: 19407.16 Da Isoelectric Point: 7.4318
>T221203 WP_045141441.1 NZ_CP085753:c156171-155650 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLVRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTALVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLVRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTALVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA
Download Length: 522 bp
>T221203 NZ_CP117359:310109-310477 [Salmonella enterica subsp. enterica serovar Dublin]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGAGCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGAGCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10248.70 Da Isoelectric Point: 5.8836
>AT221203 WP_001303459.1 NZ_CP085753:c156447-156178 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME
Download Length: 270 bp
>AT221203 NZ_CP117359:309891-310112 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|