Detailed information of TA system TA221199

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 3684347..3685260
• Replicon: chromosome
• Accession: NZ_CP085748
• Organism: Enterobacter hormaechei strain 59732CZ

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LJU46_RS18060
• Protein ID: WP_045142243.1
• Coordinates: 3684787..3685260 (+)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LJU46_RS18055
• Protein ID: WP_023296216.1
• Coordinates: 3684347..3684790 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJU46_RS18040 (LJU46_18040)	3680154..3681875	+	1722	WP_003858307.1	cysteine/glutathione ABC transporter ATP-binding protein/permease CydC	-
LJU46_RS18045 (LJU46_18045)	3681921..3682625	+	705	WP_040117448.1	leucyl/phenylalanyl-tRNA--protein transferase	-
LJU46_RS18050 (LJU46_18050)	3682910..3683128	+	219	WP_002211347.1	translation initiation factor IF-1	-
LJU46_RS18055 (LJU46_18055)	3684347..3684790	+	444	WP_023296216.1	DUF2384 domain-containing protein	Antitoxin
LJU46_RS18060 (LJU46_18060)	3684787..3685260	+	474	WP_045142243.1	RES domain-containing protein	Toxin
LJU46_RS18065 (LJU46_18065)	3685283..3685837	-	555	WP_045142244.1	type I-F CRISPR-associated endoribonuclease Cas6/Csy4	-
LJU46_RS18070 (LJU46_18070)	3685847..3686845	-	999	WP_045142245.1	type I-F CRISPR-associated protein Csy3	-
LJU46_RS18075 (LJU46_18075)	3686859..3687794	-	936	WP_045142246.1	type I-F CRISPR-associated protein Csy2	-
LJU46_RS18080 (LJU46_18080)	3687791..3689101	-	1311	WP_045142247.1	type I-F CRISPR-associated protein Csy1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-145)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17569.93 Da
• Isoelectric Point: 5.1018

>T221199 WP_045142243.1 NZ_CP085748:3684787-3685260 [Enterobacter hormaechei]
MIFYRLVTGRFASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHVRKDTVLNQYQLFSIDIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQANSALALILPSCIIPYENNAILNPLHPAFHKALNSVELMPFNFDTRLAEKTAP

Nucleotide

• Length: 474 bp

>T221199 NZ_CP117357:4668699-4669010 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16512.81 Da
• Isoelectric Point: 6.4819

>AT221199 WP_023296216.1 NZ_CP085748:3684347-3684790 [Enterobacter hormaechei]
MRTWVPAQRPADNTLWRYAGLPASRGMRLIEYLNQGLPVSVLDNIHEWTDMSKAEILRVTGINERNVARRKSTGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQLPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT221199 NZ_CP117357:4669007-4669453 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG