Detailed information of TA system TA221197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3408669..3409280
• Replicon: chromosome
• Accession: NZ_CP085748
• Organism: Enterobacter hormaechei strain 59732CZ

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: D2TUP9
• Locus tag: LJU46_RS16675
• Protein ID: WP_012906750.1
• Coordinates: 3408669..3408848 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LJU46_RS16680
• Protein ID: WP_032634114.1
• Coordinates: 3408870..3409280 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJU46_RS16650 (LJU46_16650)	3403693..3404409	+	717	WP_017384431.1	ABC transporter ATP-binding protein	-
LJU46_RS16655 (LJU46_16655)	3404575..3405045	+	471	WP_045142345.1	hypothetical protein	-
LJU46_RS16660 (LJU46_16660)	3405051..3405977	-	927	WP_063436689.1	LysR substrate-binding domain-containing protein	-
LJU46_RS16665 (LJU46_16665)	3406582..3407115	-	534	WP_032619510.1	glycosyltransferase family A protein	-
LJU46_RS16670 (LJU46_16670)	3407112..3408386	-	1275	WP_032619509.1	ATP-binding protein	-
LJU46_RS16675 (LJU46_16675)	3408669..3408848	+	180	WP_012906750.1	type II toxin-antitoxin system HicA family toxin	Toxin
LJU46_RS16680 (LJU46_16680)	3408870..3409280	+	411	WP_032634114.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LJU46_RS16685 (LJU46_16685)	3409341..3409907	+	567	WP_045342272.1	serine acetyltransferase	-
LJU46_RS16690 (LJU46_16690)	3409911..3410333	-	423	WP_045342274.1	tail fiber assembly protein	-
LJU46_RS16695 (LJU46_16695)	3410335..3412890	-	2556	WP_181494105.1	phage tail protein	-
LJU46_RS16700 (LJU46_16700)	3412893..3413444	-	552	WP_045345258.1	phage tail protein I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3403705..3453855	50150

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6644.85 Da
• Isoelectric Point: 10.9132

>T221197 WP_012906750.1 NZ_CP085748:3408669-3408848 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Nucleotide

• Length: 180 bp

>T221197 NZ_CP117357:c4346297-4345806 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14920.82 Da
• Isoelectric Point: 4.3170

>AT221197 WP_032634114.1 NZ_CP085748:3408870-3409280 [Enterobacter hormaechei]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYTGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Nucleotide

• Length: 411 bp

>AT221197 NZ_CP117357:c4346587-4346294 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Structures

Toxin

• AlphaFold DB: A0A7D6XDK4