Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2952189..2952928 Replicon chromosome
Accession NZ_CP085748
Organism Enterobacter hormaechei strain 59732CZ

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag LJU46_RS14525 Protein ID WP_003857133.1
Coordinates 2952189..2952674 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag LJU46_RS14530 Protein ID WP_003857131.1
Coordinates 2952662..2952928 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU46_RS14500 (LJU46_14500) 2947203..2948171 - 969 WP_022652343.1 IS5-like element IS903B family transposase -
LJU46_RS14505 (LJU46_14505) 2948246..2948878 + 633 WP_001567369.1 hypothetical protein -
LJU46_RS14510 (LJU46_14510) 2948907..2950309 - 1403 Protein_2818 ISNCY-like element ISKpn21 family transposase -
LJU46_RS14515 (LJU46_14515) 2950588..2951553 + 966 WP_032648329.1 hypothetical protein -
LJU46_RS14520 (LJU46_14520) 2951569..2952138 + 570 WP_032648331.1 hypothetical protein -
LJU46_RS14525 (LJU46_14525) 2952189..2952674 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
LJU46_RS14530 (LJU46_14530) 2952662..2952928 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
LJU46_RS14535 (LJU46_14535) 2952992..2953921 - 930 WP_045142163.1 LysR family transcriptional regulator -
LJU46_RS14540 (LJU46_14540) 2954051..2955439 + 1389 WP_045142139.1 MFS transporter -
LJU46_RS14545 (LJU46_14545) 2955461..2956456 - 996 WP_181494113.1 DUF2891 domain-containing protein -
LJU46_RS14550 (LJU46_14550) 2956466..2957452 - 987 WP_017382341.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T221188 WP_003857133.1 NZ_CP085748:c2952674-2952189 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T221188 NZ_CP117357:868451-868864 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT221188 WP_003857131.1 NZ_CP085748:c2952928-2952662 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT221188 NZ_CP117357:868204-868470 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References