Detailed information of TA system TA221172

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 2889346..2890013
• Replicon: chromosome
• Accession: NZ_CP085743
• Organism: Enterobacter hormaechei strain 60214CZ

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: LJU47_RS14050
• Protein ID: WP_060579732.1
• Coordinates: 2889346..2889666 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: LJU47_RS14055
• Protein ID: WP_060579733.1
• Coordinates: 2889687..2890013 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJU47_RS14005 (LJU47_14005)	2884360..2885241	+	882	WP_032608178.1	helix-turn-helix domain-containing protein	-
LJU47_RS14010 (LJU47_14010)	2885290..2885733	+	444	WP_045346041.1	GNAT family N-acetyltransferase	-
LJU47_RS14015 (LJU47_14015)	2885766..2886353	-	588	WP_023295690.1	hypothetical protein	-
LJU47_RS14020 (LJU47_14020)	2886350..2886715	-	366	WP_072034771.1	DUF2778 domain-containing protein	-
LJU47_RS14025 (LJU47_14025)	2886725..2887210	-	486	WP_045895876.1	type VI secretion system tube protein TssD	-
LJU47_RS14030 (LJU47_14030)	2887587..2887883	-	297	WP_023323949.1	SymE family type I addiction module toxin	-
LJU47_RS14035 (LJU47_14035)	2888012..2888182	+	171	WP_065186978.1	YlcI/YnfO family protein	-
LJU47_RS14040 (LJU47_14040)	2888188..2888895	+	708	WP_126542334.1	hypothetical protein	-
LJU47_RS14045 (LJU47_14045)	2888958..2889200	+	243	WP_045894635.1	hypothetical protein	-
LJU47_RS14050 (LJU47_14050)	2889346..2889666	-	321	WP_060579732.1	TA system toxin CbtA family protein	Toxin
LJU47_RS14055 (LJU47_14055)	2889687..2890013	-	327	WP_060579733.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
LJU47_RS14060 (LJU47_14060)	2890026..2890496	-	471	WP_060579734.1	DNA repair protein RadC	-
LJU47_RS14065 (LJU47_14065)	2890566..2891387	-	822	WP_060579735.1	DUF932 domain-containing protein	-
LJU47_RS14070 (LJU47_14070)	2891830..2892021	-	192	WP_072199593.1	hypothetical protein	-
LJU47_RS14075 (LJU47_14075)	2892080..2892919	-	840	WP_060579736.1	hypothetical protein	-
LJU47_RS14080 (LJU47_14080)	2892979..2893413	-	435	WP_060579737.1	hypothetical protein	-
LJU47_RS14085 (LJU47_14085)	2893722..2894885	-	1164	WP_060579738.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2870823..2907636	36813

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-98)

Antitoxin

• Antitoxin CbeA (7-107)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12078.85 Da
• Isoelectric Point: 4.7440

>T221172 WP_060579732.1 NZ_CP085743:c2889666-2889346 [Enterobacter hormaechei]
MNIQPATTPQAAKPCLSPLAVWQMLLASLLDQHYGLTLNDTPFSDETVIQKHIEAGITLADAVNFLVERYELVRIDQKGY
SVQDQEPWLTYMDVHRAQLKLNVERL

Nucleotide

• Length: 321 bp

>T221172 NZ_CP117354:c2725433-2725330 [Salmonella enterica subsp. enterica serovar Dublin]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12187.90 Da
• Isoelectric Point: 6.4729

>AT221172 WP_060579733.1 NZ_CP085743:c2890013-2889687 [Enterobacter hormaechei]
MSLIPAHEWGLKSDIVPRFGARLVQEGNRLHFLADRASLMGNFSDTECFKLNDAFPHFISQMESMLTTGELIPCHHRCVT
LYHNGFTCEADTLGSCGYVYIAVYSTQR

Nucleotide

• Length: 327 bp

>AT221172 NZ_CP117354:2725328-2725473 [Salmonella enterica subsp. enterica serovar Dublin]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG