Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 87901..88427 | Replicon | plasmid p51135CZ_IncFIB |
| Accession | NZ_CP085742 | ||
| Organism | Klebsiella pneumoniae strain 51135CZ | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | LJU38_RS27685 | Protein ID | WP_000323025.1 |
| Coordinates | 88140..88427 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | J5W3H0 |
| Locus tag | LJU38_RS27680 | Protein ID | WP_004196370.1 |
| Coordinates | 87901..88140 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJU38_RS27645 (LJU38_27645) | 83238..83430 | - | 193 | Protein_89 | MFS transporter | - |
| LJU38_RS27650 (LJU38_27650) | 83460..84437 | + | 978 | WP_004196334.1 | chromate resistance protein | - |
| LJU38_RS27655 (LJU38_27655) | 84394..85770 | + | 1377 | Protein_91 | chromate efflux transporter | - |
| LJU38_RS27660 (LJU38_27660) | 85801..86490 | - | 690 | WP_004196322.1 | hypothetical protein | - |
| LJU38_RS27665 (LJU38_27665) | 86504..87241 | - | 738 | WP_008460272.1 | HupE/UreJ family protein | - |
| LJU38_RS27670 (LJU38_27670) | 87285..87650 | - | 366 | WP_009651956.1 | hypothetical protein | - |
| LJU38_RS27675 (LJU38_27675) | 87778..87876 | - | 99 | Protein_95 | protein YdfV | - |
| LJU38_RS27680 (LJU38_27680) | 87901..88140 | + | 240 | WP_004196370.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| LJU38_RS27685 (LJU38_27685) | 88140..88427 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| LJU38_RS27690 (LJU38_27690) | 88478..89512 | - | 1035 | Protein_98 | IS481 family transposase | - |
| LJU38_RS27700 (LJU38_27700) | 89623..89742 | + | 120 | WP_159376494.1 | type I toxin-antitoxin system Hok family toxin | - |
| LJU38_RS27705 (LJU38_27705) | 90440..90712 | + | 273 | WP_032425552.1 | hypothetical protein | - |
| LJU38_RS27710 (LJU38_27710) | 90709..91059 | + | 351 | WP_032425551.1 | hypothetical protein | - |
| LJU38_RS27715 (LJU38_27715) | 91074..91391 | + | 318 | WP_015065519.1 | hypothetical protein | - |
| LJU38_RS27720 (LJU38_27720) | 92232..92588 | + | 357 | WP_019706019.1 | hypothetical protein | - |
| LJU38_RS27725 (LJU38_27725) | 92649..92861 | + | 213 | WP_019706020.1 | hypothetical protein | - |
| LJU38_RS27730 (LJU38_27730) | 92872..93096 | + | 225 | WP_014343499.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaTEM-1B | - | 1..107933 | 107933 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T221163 WP_000323025.1 NZ_CP085742:88140-88427 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T221163 NZ_CP117353:c12129-11701 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAAACAGCCACGTACGAAGACCTATATGCTCGATACCTGTATCTGTTCGTTCATCATGCGCGAGCAGTCGGAAGCGGT
GCTGAAGCGCCTTGAGCAGGCGGTGCTGCGCGGCCACCGTATCGTGATCTCGGCCATCACCTACTCCGAGATGCGCTTCG
GCGCCACCGGACCTAAGGCCTCGCCGCGTCTCGTCCAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCC
TGGGATCGCGCTGCGGTAGACGCCACCACGGAGATTAAGGTGGCACTGTGCCTCGCCGGGACGCCGATCGGTCCGAACGA
CACGGCGATTGCCGGGCATGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGG
GCCTGGTACTGGAAGACTGGGTAAGTTAA
ATGAAACAGCCACGTACGAAGACCTATATGCTCGATACCTGTATCTGTTCGTTCATCATGCGCGAGCAGTCGGAAGCGGT
GCTGAAGCGCCTTGAGCAGGCGGTGCTGCGCGGCCACCGTATCGTGATCTCGGCCATCACCTACTCCGAGATGCGCTTCG
GCGCCACCGGACCTAAGGCCTCGCCGCGTCTCGTCCAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCC
TGGGATCGCGCTGCGGTAGACGCCACCACGGAGATTAAGGTGGCACTGTGCCTCGCCGGGACGCCGATCGGTCCGAACGA
CACGGCGATTGCCGGGCATGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGG
GCCTGGTACTGGAAGACTGGGTAAGTTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9018.43 Da Isoelectric Point: 4.3894
>AT221163 WP_004196370.1 NZ_CP085742:87901-88140 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL
Download Length: 240 bp
>AT221163 NZ_CP117353:c12356-12126 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAGAACCGTATCCATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGCTTTGAGCTATGA
ATGAGAACCGTATCCATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGCTTTGAGCTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|