Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 37807..38450 | Replicon | plasmid p51135CZ_IncFIB |
| Accession | NZ_CP085742 | ||
| Organism | Klebsiella pneumoniae strain 51135CZ | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | A0A7Z7T700 |
| Locus tag | LJU38_RS27380 | Protein ID | WP_040155119.1 |
| Coordinates | 37807..38223 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | Q84A07 |
| Locus tag | LJU38_RS27385 | Protein ID | WP_001261276.1 |
| Coordinates | 38220..38450 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJU38_RS27365 (LJU38_27365) | 32851..34959 | - | 2109 | WP_032427226.1 | peptidase domain-containing ABC transporter | - |
| LJU38_RS27370 (LJU38_27370) | 34949..36226 | - | 1278 | WP_048321652.1 | HlyD family secretion protein | - |
| LJU38_RS27375 (LJU38_27375) | 36888..37766 | + | 879 | WP_009309916.1 | restriction endonuclease | - |
| LJU38_RS27380 (LJU38_27380) | 37807..38223 | - | 417 | WP_040155119.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LJU38_RS27385 (LJU38_27385) | 38220..38450 | - | 231 | WP_001261276.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LJU38_RS27390 (LJU38_27390) | 39013..39231 | + | 219 | WP_006788213.1 | type II toxin-antitoxin system antitoxin CcdA | - |
| LJU38_RS27395 (LJU38_27395) | 39233..39538 | + | 306 | WP_004197633.1 | type II toxin-antitoxin system toxin CcdB | - |
| LJU38_RS27400 (LJU38_27400) | 39767..39907 | + | 141 | WP_162898808.1 | hypothetical protein | - |
| LJU38_RS27405 (LJU38_27405) | 39957..40292 | + | 336 | WP_009309920.1 | hypothetical protein | - |
| LJU38_RS27410 (LJU38_27410) | 40471..41451 | + | 981 | WP_014386491.1 | IS5-like element ISKpn26 family transposase | - |
| LJU38_RS27415 (LJU38_27415) | 41601..41744 | + | 144 | Protein_43 | IS110 family transposase | - |
| LJU38_RS27420 (LJU38_27420) | 41761..42069 | + | 309 | Protein_44 | integrase core domain-containing protein | - |
| LJU38_RS27425 (LJU38_27425) | 42700..43440 | + | 741 | WP_001515717.1 | tyrosine-type recombinase/integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaTEM-1B | - | 1..107933 | 107933 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15147.60 Da Isoelectric Point: 7.8915
>T221161 WP_040155119.1 NZ_CP085742:c38223-37807 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPESVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIHLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFERVPGLVLEDWVK
MKKTWMLDTNICSFIMREQPESVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIHLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFERVPGLVLEDWVK
Download Length: 417 bp
>T221161 NZ_CP117351:4649044-4649355 [Salmonella enterica subsp. enterica serovar Dublin]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGATCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGATCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8721.74 Da Isoelectric Point: 4.3533
>AT221161 WP_001261276.1 NZ_CP085742:c38450-38220 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT221161 NZ_CP117351:4649352-4649798 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAATCACTCAAC
CAACACCTGGAGAAAACACCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATCAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAATCACTCAAC
CAACACCTGGAGAAAACACCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATCAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Z7T700 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A387K023 |