Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4811817..4812333 Replicon chromosome
Accession NZ_CP085740
Organism Klebsiella pneumoniae strain 51135CZ

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LJU38_RS23725 Protein ID WP_002886902.1
Coordinates 4811817..4812101 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LJU38_RS23730 Protein ID WP_002886901.1
Coordinates 4812091..4812333 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU38_RS23700 (LJU38_23700) 4807301..4807564 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LJU38_RS23705 (LJU38_23705) 4807694..4807867 + 174 WP_002886906.1 hypothetical protein -
LJU38_RS23710 (LJU38_23710) 4807870..4808613 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LJU38_RS23715 (LJU38_23715) 4808970..4811108 + 2139 WP_042943710.1 anaerobic ribonucleoside-triphosphate reductase -
LJU38_RS23720 (LJU38_23720) 4811349..4811813 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJU38_RS23725 (LJU38_23725) 4811817..4812101 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJU38_RS23730 (LJU38_23730) 4812091..4812333 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJU38_RS23735 (LJU38_23735) 4812411..4814321 - 1911 WP_004152270.1 PRD domain-containing protein -
LJU38_RS23740 (LJU38_23740) 4814344..4815498 - 1155 WP_002886900.1 lactonase family protein -
LJU38_RS23745 (LJU38_23745) 4815564..4816304 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T221158 WP_002886902.1 NZ_CP085740:c4812101-4811817 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T221158 NZ_CP117351:c4231528-4231244 [Salmonella enterica subsp. enterica serovar Dublin]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGATTAA
GAAAAAGTTGGCTGATGTGCTATTGGACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGAAGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT221158 WP_002886901.1 NZ_CP085740:c4812333-4812091 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT221158 NZ_CP117351:c4231760-4231518 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References