Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4097040..4097659 Replicon chromosome
Accession NZ_CP085740
Organism Klebsiella pneumoniae strain 51135CZ

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LJU38_RS20305 Protein ID WP_002892050.1
Coordinates 4097441..4097659 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LJU38_RS20300 Protein ID WP_002892066.1
Coordinates 4097040..4097414 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU38_RS20290 (LJU38_20290) 4092192..4093385 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LJU38_RS20295 (LJU38_20295) 4093408..4096554 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LJU38_RS20300 (LJU38_20300) 4097040..4097414 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LJU38_RS20305 (LJU38_20305) 4097441..4097659 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LJU38_RS20310 (LJU38_20310) 4097818..4098384 + 567 WP_002892030.1 maltose O-acetyltransferase -
LJU38_RS20315 (LJU38_20315) 4098356..4098496 - 141 WP_004147370.1 hypothetical protein -
LJU38_RS20320 (LJU38_20320) 4098517..4098987 + 471 WP_002892026.1 YlaC family protein -
LJU38_RS20325 (LJU38_20325) 4098962..4100413 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LJU38_RS20330 (LJU38_20330) 4100514..4101212 + 699 WP_002892021.1 GNAT family protein -
LJU38_RS20335 (LJU38_20335) 4101209..4101349 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LJU38_RS20340 (LJU38_20340) 4101349..4101612 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T221156 WP_002892050.1 NZ_CP085740:4097441-4097659 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T221156 NZ_CP117351:c4140418-4140131 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT221156 WP_002892066.1 NZ_CP085740:4097040-4097414 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT221156 NZ_CP117351:c4140144-4139842 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGATAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References