Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 827817..828474 Replicon chromosome
Accession NZ_CP085740
Organism Klebsiella pneumoniae strain 51135CZ

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LJU38_RS04225 Protein ID WP_002916310.1
Coordinates 828064..828474 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LJU38_RS04220 Protein ID WP_002916312.1
Coordinates 827817..828083 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU38_RS04195 (LJU38_04195) 822973..824406 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LJU38_RS04200 (LJU38_04200) 824525..825253 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LJU38_RS04205 (LJU38_04205) 825303..825614 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LJU38_RS04210 (LJU38_04210) 825778..826437 + 660 WP_002916317.1 hemolysin III family protein -
LJU38_RS04215 (LJU38_04215) 826588..827571 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LJU38_RS04220 (LJU38_04220) 827817..828083 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LJU38_RS04225 (LJU38_04225) 828064..828474 + 411 WP_002916310.1 protein YgfX Toxin
LJU38_RS04230 (LJU38_04230) 828481..829002 - 522 WP_002916308.1 flavodoxin FldB -
LJU38_RS04235 (LJU38_04235) 829103..829999 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LJU38_RS04240 (LJU38_04240) 830022..830735 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJU38_RS04245 (LJU38_04245) 830741..832474 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T221146 WP_002916310.1 NZ_CP085740:828064-828474 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T221146 NZ_CP117350:40347-40499 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT221146 WP_002916312.1 NZ_CP085740:827817-828083 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT221146 NZ_CP117350:c40297-40235 [Salmonella enterica subsp. enterica serovar Heidelberg]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References