Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 693050..693825 Replicon chromosome
Accession NZ_CP085740
Organism Klebsiella pneumoniae strain 51135CZ

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag LJU38_RS03505 Protein ID WP_004150910.1
Coordinates 693340..693825 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag LJU38_RS03500 Protein ID WP_004150912.1
Coordinates 693050..693343 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU38_RS03480 (LJU38_03480) 688258..688860 - 603 WP_002916735.1 short chain dehydrogenase -
LJU38_RS03485 (LJU38_03485) 688958..689869 + 912 WP_004188550.1 LysR family transcriptional regulator -
LJU38_RS03490 (LJU38_03490) 689870..691018 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
LJU38_RS03495 (LJU38_03495) 691029..692405 - 1377 WP_004217775.1 cystathionine beta-synthase -
LJU38_RS03500 (LJU38_03500) 693050..693343 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
LJU38_RS03505 (LJU38_03505) 693340..693825 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
LJU38_RS03510 (LJU38_03510) 694529..695122 + 594 WP_004188553.1 hypothetical protein -
LJU38_RS03515 (LJU38_03515) 695219..695435 + 217 Protein_691 transposase -
LJU38_RS03520 (LJU38_03520) 695743..697005 - 1263 WP_000608644.1 IS1380-like element ISEcp1 family transposase -
LJU38_RS03525 (LJU38_03525) 697702..698574 + 873 WP_004188557.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T221145 WP_004150910.1 NZ_CP085740:693340-693825 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T221145 NZ_CP117349:c14266-13916 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT221145 WP_004150912.1 NZ_CP085740:693050-693343 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT221145 NZ_CP117349:c13911-13609 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References