Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4626432..4627051 Replicon chromosome
Accession NZ_CP085729
Organism Klebsiella pneumoniae strain 59062CZ

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LJU45_RS23090 Protein ID WP_002892050.1
Coordinates 4626432..4626650 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LJU45_RS23095 Protein ID WP_002892066.1
Coordinates 4626677..4627051 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU45_RS23055 (LJU45_23055) 4622479..4622742 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
LJU45_RS23060 (LJU45_23060) 4622742..4622882 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LJU45_RS23065 (LJU45_23065) 4622879..4623577 - 699 WP_002892021.1 GNAT family protein -
LJU45_RS23070 (LJU45_23070) 4623678..4625129 + 1452 WP_029602518.1 PLP-dependent aminotransferase family protein -
LJU45_RS23075 (LJU45_23075) 4625104..4625574 - 471 WP_002892026.1 YlaC family protein -
LJU45_RS23080 (LJU45_23080) 4625595..4625735 + 141 WP_032410934.1 hypothetical protein -
LJU45_RS23085 (LJU45_23085) 4625707..4626273 - 567 WP_002892030.1 maltose O-acetyltransferase -
LJU45_RS23090 (LJU45_23090) 4626432..4626650 - 219 WP_002892050.1 HHA domain-containing protein Toxin
LJU45_RS23095 (LJU45_23095) 4626677..4627051 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LJU45_RS23100 (LJU45_23100) 4627537..4630683 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LJU45_RS23105 (LJU45_23105) 4630706..4631899 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T221138 WP_002892050.1 NZ_CP085729:c4626650-4626432 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T221138 NZ_CP117348:2403184-2403468 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAAATGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGTTACGGGAACGTCTTGAAAACCCTCGGGTTCCGGCTTCGCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT221138 WP_002892066.1 NZ_CP085729:c4627051-4626677 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT221138 NZ_CP117348:2402946-2403194 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References