Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3933791..3934307 Replicon chromosome
Accession NZ_CP085729
Organism Klebsiella pneumoniae strain 59062CZ

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LJU45_RS19770 Protein ID WP_004178374.1
Coordinates 3934023..3934307 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LJU45_RS19765 Protein ID WP_002886901.1
Coordinates 3933791..3934033 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU45_RS19750 (LJU45_19750) 3929819..3930559 + 741 WP_002886899.1 KDGP aldolase family protein -
LJU45_RS19755 (LJU45_19755) 3930626..3931780 + 1155 WP_023280781.1 lactonase family protein -
LJU45_RS19760 (LJU45_19760) 3931803..3933713 + 1911 WP_004152270.1 PRD domain-containing protein -
LJU45_RS19765 (LJU45_19765) 3933791..3934033 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJU45_RS19770 (LJU45_19770) 3934023..3934307 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJU45_RS19775 (LJU45_19775) 3934311..3934775 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJU45_RS19780 (LJU45_19780) 3935110..3937248 - 2139 WP_004222153.1 anaerobic ribonucleoside-triphosphate reductase -
LJU45_RS19785 (LJU45_19785) 3937605..3938348 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LJU45_RS19790 (LJU45_19790) 3938351..3938524 - 174 WP_032431440.1 hypothetical protein -
LJU45_RS19795 (LJU45_19795) 3938654..3938917 + 264 WP_014908078.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T221136 WP_004178374.1 NZ_CP085729:3934023-3934307 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T221136 NZ_CP117348:c1023419-1022892 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTACAACGCCATGCACTACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATATTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT221136 WP_002886901.1 NZ_CP085729:3933791-3934033 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT221136 NZ_CP117348:c1023706-1023416 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGACTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References