Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2542322..2542979 Replicon chromosome
Accession NZ_CP085729
Organism Klebsiella pneumoniae strain 59062CZ

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LJU45_RS12895 Protein ID WP_002916310.1
Coordinates 2542322..2542732 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LJU45_RS12900 Protein ID WP_002916312.1
Coordinates 2542713..2542979 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU45_RS12875 (LJU45_12875) 2538322..2540055 - 1734 WP_029602145.1 single-stranded-DNA-specific exonuclease RecJ -
LJU45_RS12880 (LJU45_12880) 2540061..2540774 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJU45_RS12885 (LJU45_12885) 2540797..2541693 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LJU45_RS12890 (LJU45_12890) 2541794..2542315 + 522 WP_002916308.1 flavodoxin FldB -
LJU45_RS12895 (LJU45_12895) 2542322..2542732 - 411 WP_002916310.1 protein YgfX Toxin
LJU45_RS12900 (LJU45_12900) 2542713..2542979 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LJU45_RS12905 (LJU45_12905) 2543225..2544208 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LJU45_RS12910 (LJU45_12910) 2544307..2544966 - 660 WP_002916317.1 hemolysin III family protein -
LJU45_RS12915 (LJU45_12915) 2545130..2545441 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LJU45_RS12920 (LJU45_12920) 2545491..2546219 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LJU45_RS12925 (LJU45_12925) 2546338..2547771 + 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T221132 WP_002916310.1 NZ_CP085729:c2542732-2542322 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T221132 NZ_CP117347:134245-134595 [Salmonella enterica subsp. enterica serovar Dublin]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT221132 WP_002916312.1 NZ_CP085729:c2542979-2542713 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT221132 NZ_CP117347:134600-134902 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References