Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 336942..337584 Replicon chromosome
Accession NZ_CP085717
Organism Peribacillus asahii strain CMF4

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag LIS76_RS01775 Protein ID WP_119118987.1
Coordinates 337234..337584 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag LIS76_RS01770 Protein ID WP_119118988.1
Coordinates 336942..337226 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIS76_RS01750 (LIS76_01750) 333008..333589 - 582 WP_252292735.1 rhomboid family intramembrane serine protease -
LIS76_RS01755 (LIS76_01755) 333667..334029 + 363 WP_252288568.1 holo-ACP synthase -
LIS76_RS01760 (LIS76_01760) 334341..335351 + 1011 WP_252292736.1 outer membrane lipoprotein carrier protein LolA -
LIS76_RS01765 (LIS76_01765) 335630..336784 + 1155 WP_252295363.1 alanine racemase -
LIS76_RS01770 (LIS76_01770) 336942..337226 + 285 WP_119118988.1 antitoxin endoai Antitoxin
LIS76_RS01775 (LIS76_01775) 337234..337584 + 351 WP_119118987.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LIS76_RS01780 (LIS76_01780) 338145..340313 + 2169 WP_252295364.1 Tex family protein -
LIS76_RS01785 (LIS76_01785) 340366..340485 - 120 WP_119118989.1 cortex morphogenetic protein CmpA -
LIS76_RS01790 (LIS76_01790) 340575..341036 + 462 WP_252292737.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13000.10 Da        Isoelectric Point: 8.4631

>T221121 WP_119118987.1 NZ_CP085717:337234-337584 [Peribacillus asahii]
IVVKRGDVYFADLSPVVGSEQGGTRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQI
RTIDKQRLTDKITYLDETMMQKVNEALQISLGLKEF

Download         Length: 351 bp

>T221121 NZ_CP117346:3545926-3546144 [Salmonella enterica subsp. enterica serovar Dublin]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10740.05 Da        Isoelectric Point: 4.7348

>AT221121 WP_119118988.1 NZ_CP085717:336942-337226 [Peribacillus asahii]
VSESGATREIIIRLPQNVLTELDGYASEENVNRSEFIYRATTMYLRKKKEFRESMKRGYIEMAAINLTIASEAFQAEYPE
YEAEHAVERLASGG

Download         Length: 285 bp

>AT221121 NZ_CP117346:3545524-3545898 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References