Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pemIK/MazF(toxin) |
| Location | 342491..343133 | Replicon | chromosome |
| Accession | NZ_CP085714 | ||
| Organism | Peribacillus asahii strain CK1 | ||
Toxin (Protein)
| Gene name | pemK | Uniprot ID | - |
| Locus tag | LIT37_RS01840 | Protein ID | WP_119118987.1 |
| Coordinates | 342783..343133 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | pemI | Uniprot ID | - |
| Locus tag | LIT37_RS01835 | Protein ID | WP_119118988.1 |
| Coordinates | 342491..342775 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LIT37_RS01815 (LIT37_01815) | 338560..339141 | - | 582 | WP_252288566.1 | rhomboid family intramembrane serine protease | - |
| LIT37_RS01820 (LIT37_01820) | 339219..339581 | + | 363 | WP_252288568.1 | holo-ACP synthase | - |
| LIT37_RS01825 (LIT37_01825) | 339891..340901 | + | 1011 | WP_252288570.1 | outer membrane lipoprotein carrier protein LolA | - |
| LIT37_RS01830 (LIT37_01830) | 341180..342334 | + | 1155 | WP_252291267.1 | alanine racemase | - |
| LIT37_RS01835 (LIT37_01835) | 342491..342775 | + | 285 | WP_119118988.1 | antitoxin endoai | Antitoxin |
| LIT37_RS01840 (LIT37_01840) | 342783..343133 | + | 351 | WP_119118987.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| LIT37_RS01845 (LIT37_01845) | 343432..345600 | + | 2169 | WP_252291269.1 | Tex family protein | - |
| LIT37_RS01850 (LIT37_01850) | 345652..345771 | - | 120 | WP_119118989.1 | cortex morphogenetic protein CmpA | - |
| LIT37_RS01855 (LIT37_01855) | 345861..346322 | + | 462 | WP_252288572.1 | SprT family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13000.10 Da Isoelectric Point: 8.4631
>T221120 WP_119118987.1 NZ_CP085714:342783-343133 [Peribacillus asahii]
IVVKRGDVYFADLSPVVGSEQGGTRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQI
RTIDKQRLTDKITYLDETMMQKVNEALQISLGLKEF
IVVKRGDVYFADLSPVVGSEQGGTRPVLILQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQI
RTIDKQRLTDKITYLDETMMQKVNEALQISLGLKEF
Download Length: 351 bp
>T221120 NZ_CP117346:c2726136-2726033 [Salmonella enterica subsp. enterica serovar Dublin]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 95 a.a. Molecular weight: 10740.05 Da Isoelectric Point: 4.7348
>AT221120 WP_119118988.1 NZ_CP085714:342491-342775 [Peribacillus asahii]
VSESGATREIIIRLPQNVLTELDGYASEENVNRSEFIYRATTMYLRKKKEFRESMKRGYIEMAAINLTIASEAFQAEYPE
YEAEHAVERLASGG
VSESGATREIIIRLPQNVLTELDGYASEENVNRSEFIYRATTMYLRKKKEFRESMKRGYIEMAAINLTIASEAFQAEYPE
YEAEHAVERLASGG
Download Length: 285 bp
>AT221120 NZ_CP117346:2726031-2726176 [Salmonella enterica subsp. enterica serovar Dublin]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|