Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 4314903..4315491 Replicon chromosome
Accession NZ_CP085704
Organism Pseudomonas sp. HN2-3

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LJX93_RS19550 Protein ID WP_095063759.1
Coordinates 4314903..4315205 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LJX93_RS19555 Protein ID WP_095063760.1
Coordinates 4315198..4315491 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJX93_RS27325 4310902..4311030 - 129 WP_256214945.1 PA1414 family protein -
LJX93_RS19530 (LJX93_19530) 4311156..4312049 - 894 WP_033699637.1 LysR family transcriptional regulator -
LJX93_RS19535 (LJX93_19535) 4312155..4313336 + 1182 WP_047583464.1 MFS transporter -
LJX93_RS19540 (LJX93_19540) 4313346..4314272 - 927 WP_033699642.1 DMT family transporter -
LJX93_RS19545 (LJX93_19545) 4314379..4314774 - 396 WP_033699644.1 transcriptional regulator -
LJX93_RS19550 (LJX93_19550) 4314903..4315205 + 303 WP_095063759.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJX93_RS19555 (LJX93_19555) 4315198..4315491 + 294 WP_095063760.1 putative addiction module antidote protein Antitoxin
LJX93_RS19560 (LJX93_19560) 4315604..4315876 + 273 WP_033699650.1 hypothetical protein -
LJX93_RS19565 (LJX93_19565) 4315931..4317292 - 1362 WP_033699652.1 DEAD/DEAH box helicase -
LJX93_RS19570 (LJX93_19570) 4317397..4318698 + 1302 WP_033699654.1 mechanosensitive ion channel family protein -
LJX93_RS19575 (LJX93_19575) 4318743..4318946 - 204 WP_033699656.1 hypothetical protein -
LJX93_RS19580 (LJX93_19580) 4318957..4319832 - 876 WP_033699658.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-87)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11485.17 Da        Isoelectric Point: 10.6088

>T221115 WP_095063759.1 NZ_CP085704:4314903-4315205 [Pseudomonas sp. HN2-3]
MKKIESSSFRHWVHGLRDDTARIRIIARINRLMEGLPGDVSAVGHGVSELRIHYGPGYRVYFHQSGDTLVILLCGGHKSS
QRRDIKAAHEILRSWRMQHD

Download         Length: 303 bp

>T221115 NZ_CP117346:310112-310480 [Salmonella enterica subsp. enterica serovar Dublin]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGAGCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10517.96 Da        Isoelectric Point: 5.5740

>AT221115 WP_095063760.1 NZ_CP085704:4315198-4315491 [Pseudomonas sp. HN2-3]
MTETFFDFDAADYLTTPQAIAQFMSDALETGDASYVAKAVGVVARAKGMSELAKETGLSREQLYRSFSEHGNPTLKSFLA
VMKALGIDMTAKPHLAH

Download         Length: 294 bp

>AT221115 NZ_CP117346:309894-310115 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References