Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1079231..1080019 Replicon chromosome
Accession NC_009487
Organism Staphylococcus aureus subsp. aureus JH9

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag SAURJH9_RS05445 Protein ID WP_000525004.1
Coordinates 1079231..1079692 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag SAURJH9_RS05450 Protein ID WP_000333630.1
Coordinates 1079705..1080019 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAURJH9_RS05420 1075219..1076022 + 804 WP_000928413.1 TerC family protein -
SAURJH9_RS05425 1076311..1077516 - 1206 WP_000264741.1 site-specific integrase -
SAURJH9_RS05430 1077642..1078256 + 615 WP_000191459.1 hypothetical protein -
SAURJH9_RS05435 1078253..1078399 - 147 WP_001013104.1 hypothetical protein -
SAURJH9_RS05440 1078629..1079213 - 585 WP_000825948.1 hypothetical protein -
SAURJH9_RS05445 1079231..1079692 - 462 WP_000525004.1 hypothetical protein Toxin
SAURJH9_RS05450 1079705..1080019 - 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
SAURJH9_RS05455 1080171..1080407 + 237 WP_001121027.1 helix-turn-helix domain-containing protein -
SAURJH9_RS05460 1080421..1081197 + 777 WP_001148544.1 Rha family transcriptional regulator -
SAURJH9_RS05465 1081226..1081369 + 144 WP_000939498.1 hypothetical protein -
SAURJH9_RS05470 1081359..1081568 - 210 WP_000642492.1 hypothetical protein -
SAURJH9_RS05475 1081624..1081869 + 246 WP_001025401.1 DUF2829 domain-containing protein -
SAURJH9_RS05480 1081838..1082203 - 366 WP_001128433.1 hypothetical protein -
SAURJH9_RS05485 1082258..1082473 + 216 WP_001097552.1 hypothetical protein -
SAURJH9_RS05490 1082498..1082761 + 264 WP_001124160.1 helix-turn-helix domain-containing protein -
SAURJH9_RS05495 1082774..1082935 + 162 WP_001285954.1 DUF1270 domain-containing protein -
SAURJH9_RS05500 1083014..1083337 + 324 WP_000175002.1 hypothetical protein -
SAURJH9_RS05505 1083352..1083714 + 363 WP_000985976.1 hypothetical protein -
SAURJH9_RS05510 1083711..1084877 + 1167 WP_000762547.1 DUF2800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1076311..1121184 44873


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T22111 WP_000525004.1 NC_009487:c1079692-1079231 [Staphylococcus aureus subsp. aureus JH9]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T22111 NC_009487:c1079692-1079231 [Staphylococcus aureus subsp. aureus JH9]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT22111 WP_000333630.1 NC_009487:c1080019-1079705 [Staphylococcus aureus subsp. aureus JH9]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT22111 NC_009487:c1080019-1079705 [Staphylococcus aureus subsp. aureus JH9]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References