Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4446013..4446794 | Replicon | chromosome |
| Accession | NZ_CP085699 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain S29 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | LJN59_RS21850 | Protein ID | WP_000626099.1 |
| Coordinates | 4446013..4446504 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | LJN59_RS21855 | Protein ID | WP_001110452.1 |
| Coordinates | 4446501..4446794 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJN59_RS21810 (4441199) | 4441199..4441441 | - | 243 | WP_197603740.1 | hypothetical protein | - |
| LJN59_RS21815 (4441438) | 4441438..4441794 | - | 357 | WP_033567083.1 | hypothetical protein | - |
| LJN59_RS21820 (4441791) | 4441791..4442663 | - | 873 | WP_033567082.1 | ParA family protein | - |
| LJN59_RS21825 (4442854) | 4442854..4442931 | - | 78 | Protein_4270 | helix-turn-helix domain-containing protein | - |
| LJN59_RS21830 (4443022) | 4443022..4443354 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| LJN59_RS21835 (4443426) | 4443426..4443803 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| LJN59_RS21840 (4444836) | 4444836..4444910 | + | 75 | Protein_4273 | porin family protein | - |
| LJN59_RS21845 (4445013) | 4445013..4445765 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| LJN59_RS21850 (4446013) | 4446013..4446504 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| LJN59_RS21855 (4446501) | 4446501..4446794 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| LJN59_RS21860 (4447111) | 4447111..4447332 | + | 222 | WP_001576552.1 | hypothetical protein | - |
| LJN59_RS21865 (4447597) | 4447597..4448472 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| LJN59_RS21870 (4448469) | 4448469..4448756 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| LJN59_RS21875 (4448779) | 4448779..4448994 | + | 216 | WP_001595136.1 | hypothetical protein | - |
| LJN59_RS21880 (4449002) | 4449002..4449271 | + | 270 | WP_010989096.1 | hypothetical protein | - |
| LJN59_RS21885 (4449565) | 4449565..4450470 | - | 906 | WP_001268200.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T221107 WP_000626099.1 NZ_CP085699:c4446504-4446013 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T221107 NZ_CP117343:c4344055-4343564 [Salmonella enterica subsp. enterica serovar Dublin]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAGCGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAAGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAGCGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAAGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT221107 WP_001110452.1 NZ_CP085699:c4446794-4446501 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT221107 NZ_CP117343:c4344345-4344052 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCCGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCCTATCAGGAATTTCTGGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCCGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCCTATCAGGAATTTCTGGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|