Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4235935..4236451 Replicon chromosome
Accession NZ_CP085699
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S29

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag LJN59_RS20745 Protein ID WP_000220578.1
Coordinates 4235935..4236219 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LJN59_RS20750 Protein ID WP_000212724.1
Coordinates 4236209..4236451 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJN59_RS20730 (4231147) 4231147..4232799 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
LJN59_RS20735 (4233208) 4233208..4235346 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LJN59_RS20740 (4235467) 4235467..4235931 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJN59_RS20745 (4235935) 4235935..4236219 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJN59_RS20750 (4236209) 4236209..4236451 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJN59_RS20755 (4236529) 4236529..4238442 - 1914 WP_001212137.1 BglG family transcription antiterminator -
LJN59_RS20760 (4238459) 4238459..4239199 - 741 WP_000779263.1 KDGP aldolase family protein -
LJN59_RS20765 (4239196) 4239196..4240314 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LJN59_RS20770 (4240298) 4240298..4241431 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T221106 WP_000220578.1 NZ_CP085699:c4236219-4235935 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T221106 NZ_CP117343:c4236908-4236624 [Salmonella enterica subsp. enterica serovar Dublin]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGATTAA
GAAAAAGTTGGCTGATGTGCTATTGGACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGAAGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT221106 WP_000212724.1 NZ_CP085699:c4236451-4236209 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT221106 NZ_CP117343:c4237140-4236898 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References