Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4140897..4141473 Replicon chromosome
Accession NZ_CP085699
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S29

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag LJN59_RS20340 Protein ID WP_001131963.1
Coordinates 4141186..4141473 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag LJN59_RS20335 Protein ID WP_000063142.1
Coordinates 4140897..4141199 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJN59_RS20320 (4137407) 4137407..4139557 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
LJN59_RS20325 (4139652) 4139652..4139855 + 204 WP_000460616.1 YbdD/YjiX family protein -
LJN59_RS20330 (4139866) 4139866..4140822 + 957 WP_000187839.1 GTPase -
LJN59_RS20335 (4140897) 4140897..4141199 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
LJN59_RS20340 (4141186) 4141186..4141473 - 288 WP_001131963.1 BrnT family toxin Toxin
LJN59_RS20345 (4141742) 4141742..4142656 - 915 WP_000290512.1 restriction endonuclease -
LJN59_RS20350 (4142854) 4142854..4146363 + 3510 WP_001043484.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T221105 WP_001131963.1 NZ_CP085699:c4141473-4141186 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T221105 NZ_CP117343:c4195767-4195459 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT221105 WP_000063142.1 NZ_CP085699:c4141199-4140897 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT221105 NZ_CP117343:c4196009-4195770 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References