Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3521982..3522602 Replicon chromosome
Accession NZ_CP085699
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S29

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJN59_RS17460 Protein ID WP_001280991.1
Coordinates 3522384..3522602 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJN59_RS17455 Protein ID WP_000344807.1
Coordinates 3521982..3522356 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJN59_RS17445 (3517121) 3517121..3518314 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LJN59_RS17450 (3518337) 3518337..3521486 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJN59_RS17455 (3521982) 3521982..3522356 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJN59_RS17460 (3522384) 3522384..3522602 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LJN59_RS17465 (3522781) 3522781..3523332 + 552 WP_001278792.1 maltose O-acetyltransferase -
LJN59_RS17470 (3523449) 3523449..3523919 + 471 WP_000136181.1 YlaC family protein -
LJN59_RS17475 (3523975) 3523975..3524115 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJN59_RS17480 (3524121) 3524121..3524381 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJN59_RS17485 (3524606) 3524606..3526156 + 1551 WP_000213139.1 EAL domain-containing protein -
LJN59_RS17495 (3526387) 3526387..3526776 + 390 WP_000961285.1 MGMT family protein -
LJN59_RS17500 (3526809) 3526809..3527378 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T221101 WP_001280991.1 NZ_CP085699:3522384-3522602 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T221101 NZ_CP117343:c2725811-2725708 [Salmonella enterica subsp. enterica serovar Dublin]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT221101 WP_000344807.1 NZ_CP085699:3521982-3522356 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT221101 NZ_CP117343:2725706-2725851 [Salmonella enterica subsp. enterica serovar Dublin]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References