Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 363292..364089 Replicon chromosome
Accession NC_009487
Organism Staphylococcus aureus subsp. aureus JH9

Toxin (Protein)


Gene name - Uniprot ID A0A6B0AWK0
Locus tag SAURJH9_RS01615 Protein ID WP_000525016.1
Coordinates 363292..363753 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag SAURJH9_RS01620 Protein ID WP_001260487.1
Coordinates 363766..364089 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAURJH9_RS01595 359131..361065 + 1935 Protein_309 YSIRK domain-containing triacylglycerol lipase Lip2/Geh -
SAURJH9_RS01600 361159..362364 - 1206 WP_000264186.1 site-specific integrase -
SAURJH9_RS01605 362475..362654 + 180 WP_000337827.1 hypothetical protein -
SAURJH9_RS01610 362780..363271 - 492 WP_001077638.1 hypothetical protein -
SAURJH9_RS01615 363292..363753 - 462 WP_000525016.1 hypothetical protein Toxin
SAURJH9_RS01620 363766..364089 - 324 WP_001260487.1 helix-turn-helix domain-containing protein Antitoxin
SAURJH9_RS01625 364253..364501 + 249 WP_000272858.1 helix-turn-helix domain-containing protein -
SAURJH9_RS15975 364516..364677 + 162 WP_001153175.1 hypothetical protein -
SAURJH9_RS01630 364670..364963 - 294 WP_044118938.1 hypothetical protein -
SAURJH9_RS01635 365357..365542 + 186 WP_000933365.1 helix-turn-helix transcriptional regulator -
SAURJH9_RS01640 365544..366296 + 753 WP_001148634.1 phage antirepressor KilAC domain-containing protein -
SAURJH9_RS01645 366312..366530 + 219 WP_000993180.1 hypothetical protein -
SAURJH9_RS01650 366560..366823 + 264 WP_001124198.1 helix-turn-helix domain-containing protein -
SAURJH9_RS01655 366835..366996 + 162 WP_000066020.1 DUF1270 domain-containing protein -
SAURJH9_RS01660 367091..367393 + 303 WP_000165371.1 DUF2482 family protein -
SAURJH9_RS01665 367398..367658 + 261 WP_000291510.1 DUF1108 family protein -
SAURJH9_RS15155 367667..367930 + 264 WP_001205732.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 361159..403422 42263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 17993.29 Da        Isoelectric Point: 4.5941

>T22109 WP_000525016.1 NC_009487:c363753-363292 [Staphylococcus aureus subsp. aureus JH9]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDTEKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFTSAVPIREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T22109 NC_009487:c363753-363292 [Staphylococcus aureus subsp. aureus JH9]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATCTAATTTTAATAAAGCGTGGTTTATCAGATACAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCTGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTATGCACGT
AGACATGGTTTTACTTCAGCTGTACCGATACGTGAAATTGTAGAAGCTTACAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTGGAGGCAATAGAACAATATAAGAAGATATACGGTATTGGAACTC
ACTATGGCGAGTATTCGATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAAGAAATATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT22109 WP_001260487.1 NC_009487:c364089-363766 [Staphylococcus aureus subsp. aureus JH9]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT22109 NC_009487:c364089-363766 [Staphylococcus aureus subsp. aureus JH9]
ATGAGAACTTCAGCAGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGAGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B0AWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References