Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 873011..873671 Replicon chromosome
Accession NZ_CP085699
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain S29

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LJN59_RS04250 Protein ID WP_000244756.1
Coordinates 873258..873671 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJN59_RS04245 Protein ID WP_000351186.1
Coordinates 873011..873277 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJN59_RS04225 (868939) 868939..870372 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
LJN59_RS04230 (870531) 870531..870842 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LJN59_RS04235 (871006) 871006..871665 + 660 WP_000250289.1 hemolysin III family protein -
LJN59_RS04240 (871781) 871781..872761 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
LJN59_RS04245 (873011) 873011..873277 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJN59_RS04250 (873258) 873258..873671 + 414 WP_000244756.1 protein YgfX Toxin
LJN59_RS04255 (873724) 873724..874245 - 522 WP_001055885.1 flavodoxin FldB -
LJN59_RS04260 (874358) 874358..875254 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJN59_RS04265 (875278) 875278..875991 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJN59_RS04270 (875997) 875997..877730 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T221089 WP_000244756.1 NZ_CP085699:873258-873671 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T221089 NZ_CP117340:c4650993-4650682 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT221089 WP_000351186.1 NZ_CP085699:873011-873277 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT221089 NZ_CP117340:c4650681-4650391 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References