Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 84583..86206 Replicon plasmid pS25-IncHI2
Accession NZ_CP085697
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain S25

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag LJN58_RS24280 Protein ID WP_000088046.1
Coordinates 84881..86206 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag LJN58_RS24275 Protein ID WP_024136327.1
Coordinates 84583..84876 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJN58_RS24250 (LJN58_24250) 80455..81696 + 1242 WP_140902854.1 VWA domain-containing protein -
LJN58_RS25235 81787..81918 + 132 WP_000374059.1 hypothetical protein -
LJN58_RS24255 (LJN58_24255) 82259..82540 - 282 WP_000077926.1 hypothetical protein -
LJN58_RS24260 (LJN58_24260) 82590..82781 - 192 WP_000398480.1 hypothetical protein -
LJN58_RS24265 (LJN58_24265) 82873..83214 - 342 WP_001151575.1 hypothetical protein -
LJN58_RS24270 (LJN58_24270) 83587..83979 + 393 WP_000341066.1 hypothetical protein -
LJN58_RS24275 (LJN58_24275) 84583..84876 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
LJN58_RS24280 (LJN58_24280) 84881..86206 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
LJN58_RS24285 (LJN58_24285) 86267..86473 + 207 WP_000134171.1 hypothetical protein -
LJN58_RS24290 (LJN58_24290) 86575..86985 + 411 WP_000985911.1 hypothetical protein -
LJN58_RS24295 (LJN58_24295) 86998..87813 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
LJN58_RS24300 (LJN58_24300) 88067..88492 + 426 WP_001043843.1 hypothetical protein -
LJN58_RS24305 (LJN58_24305) 89041..89349 + 309 WP_001224687.1 hypothetical protein -
LJN58_RS24310 (LJN58_24310) 89365..90222 + 858 WP_000784387.1 HNH endonuclease signature motif containing protein -
LJN58_RS24315 (LJN58_24315) 90284..90487 + 204 WP_001194555.1 hypothetical protein -
LJN58_RS24320 (LJN58_24320) 90829..91185 - 357 WP_065311124.1 H-NS family nucleoid-associated regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-Ia / tet(A) / aph(6)-Id / floR / blaLAP-2 / blaTEM-1B / blaCTX-M-55 / qnrS1 / mph(A) / ARR-3 / dfrA14 - 1..237710 237710


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T221085 WP_000088046.1 NZ_CP085697:84881-86206 [Salmonella enterica subsp. enterica serovar Saintpaul]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T221085 NZ_CP117340:c4143589-4143302 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT221085 WP_024136327.1 NZ_CP085697:84583-84876 [Salmonella enterica subsp. enterica serovar Saintpaul]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT221085 NZ_CP117340:c4143315-4143013 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGATAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References