Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4351350..4352131 Replicon chromosome
Accession NZ_CP085696
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain S25

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A5I5SY00
Locus tag LJN58_RS21505 Protein ID WP_000626104.1
Coordinates 4351350..4351841 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJN58_RS21510 Protein ID WP_001110452.1
Coordinates 4351838..4352131 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJN58_RS21480 (4346490) 4346490..4348928 - 2439 WP_001014138.1 F4 (K88) fimbrial usher FaeD -
LJN58_RS21485 (4348938) 4348938..4349477 - 540 WP_000721295.1 type 1 fimbrial protein -
LJN58_RS21490 (4349512) 4349512..4349796 - 285 WP_205903706.1 PapB/FocB family fimbrial expression transcriptional regulator -
LJN58_RS21495 (4350385) 4350385..4350612 + 228 WP_001519955.1 hypothetical protein -
LJN58_RS21500 (4350887) 4350887..4351135 - 249 Protein_4199 IS481 family transposase -
LJN58_RS21505 (4351350) 4351350..4351841 - 492 WP_000626104.1 GNAT family N-acetyltransferase Toxin
LJN58_RS21510 (4351838) 4351838..4352131 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJN58_RS21515 (4352448) 4352448..4352669 + 222 WP_021001044.1 hypothetical protein -
LJN58_RS21520 (4352935) 4352935..4353810 + 876 WP_000921676.1 AraC family transcriptional regulator -
LJN58_RS21525 (4353807) 4353807..4354094 + 288 WP_001269916.1 transcriptional regulator RtsB -
LJN58_RS21530 (4354117) 4354117..4354332 + 216 WP_001595136.1 hypothetical protein -
LJN58_RS21535 (4354340) 4354340..4354609 + 270 WP_010989096.1 hypothetical protein -
LJN58_RS21540 (4354903) 4354903..4355808 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4339714..4354609 14895


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17631.42 Da        Isoelectric Point: 7.7297

>T221082 WP_000626104.1 NZ_CP085696:c4351841-4351350 [Salmonella enterica subsp. enterica serovar Saintpaul]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221082 NZ_CP117340:c2725870-2725767 [Salmonella enterica subsp. enterica serovar Dublin]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221082 WP_001110452.1 NZ_CP085696:c4352131-4351838 [Salmonella enterica subsp. enterica serovar Saintpaul]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221082 NZ_CP117340:2725765-2725910 [Salmonella enterica subsp. enterica serovar Dublin]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5SY00

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References