Detailed information of TA system TA221081

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4212628..4213144
• Replicon: chromosome
• Accession: NZ_CP085696
• Organism: Salmonella enterica subsp. enterica serovar Saintpaul strain S25

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7U1KST9
• Locus tag: LJN58_RS20775
• Protein ID: WP_000220585.1
• Coordinates: 4212628..4212912 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7U1KSR8
• Locus tag: LJN58_RS20780
• Protein ID: WP_000212721.1
• Coordinates: 4212902..4213144 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJN58_RS20760 (4207744)	4207744..4209396	+	1653	WP_000155065.1	alpha,alpha-phosphotrehalase	-
LJN58_RS20765 (4209805)	4209805..4211943	+	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
LJN58_RS20770 (4212160)	4212160..4212624	+	465	WP_001009173.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LJN58_RS20775 (4212628)	4212628..4212912	-	285	WP_000220585.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LJN58_RS20780 (4212902)	4212902..4213144	-	243	WP_000212721.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LJN58_RS20785 (4213222)	4213222..4215135	-	1914	WP_001212126.1	BglG family transcription antiterminator	-
LJN58_RS20790 (4215152)	4215152..4215892	-	741	WP_000779253.1	KDGP aldolase family protein	-
LJN58_RS20795 (4215889)	4215889..4217007	-	1119	WP_001139191.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
LJN58_RS20800 (4216991)	4216991..4218124	-	1134	WP_000459929.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-65)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10878.69 Da
• Isoelectric Point: 9.8739

>T221081 WP_000220585.1 NZ_CP085696:c4212912-4212628 [Salmonella enterica subsp. enterica serovar Saintpaul]
MTYELEIDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T221081 NZ_CP117340:c987369-986842 [Salmonella enterica subsp. enterica serovar Dublin]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTACAACGCCATGCACTACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8995.36 Da
• Isoelectric Point: 5.0651

>AT221081 WP_000212721.1 NZ_CP085696:c4213144-4212902 [Salmonella enterica subsp. enterica serovar Saintpaul]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTFSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT221081 NZ_CP117340:c987656-987366 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGACTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Toxin

• AlphaFold DB: A0A7U1KST9

Antitoxin

• AlphaFold DB: A0A7U1KSR8