Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4120001..4120577 Replicon chromosome
Accession NZ_CP085696
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain S25

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag LJN58_RS20370 Protein ID WP_001131963.1
Coordinates 4120290..4120577 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag LJN58_RS20365 Protein ID WP_000063142.1
Coordinates 4120001..4120303 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJN58_RS20350 (4116511) 4116511..4118661 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
LJN58_RS20355 (4118756) 4118756..4118959 + 204 WP_000460616.1 YbdD/YjiX family protein -
LJN58_RS20360 (4118970) 4118970..4119926 + 957 WP_000187839.1 GTPase -
LJN58_RS20365 (4120001) 4120001..4120303 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
LJN58_RS20370 (4120290) 4120290..4120577 - 288 WP_001131963.1 BrnT family toxin Toxin
LJN58_RS20375 (4120846) 4120846..4121760 - 915 WP_000290512.1 restriction endonuclease -
LJN58_RS20380 (4121958) 4121958..4125467 + 3510 WP_001043484.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T221080 WP_001131963.1 NZ_CP085696:c4120577-4120290 [Salmonella enterica subsp. enterica serovar Saintpaul]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T221080 NZ_CP085696:c4120577-4120290 [Salmonella enterica subsp. enterica serovar Saintpaul]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT221080 WP_000063142.1 NZ_CP085696:c4120303-4120001 [Salmonella enterica subsp. enterica serovar Saintpaul]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT221080 NZ_CP085696:c4120303-4120001 [Salmonella enterica subsp. enterica serovar Saintpaul]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References