Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1460897..1461342 Replicon chromosome
Accession NC_009486
Organism Thermotoga petrophila RKU-1

Toxin (Protein)


Gene name hicA Uniprot ID D2C4B8
Locus tag TPET_RS07530 Protein ID WP_008195297.1
Coordinates 1461112..1461342 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID Q9X145
Locus tag TPET_RS07525 Protein ID WP_004083352.1
Coordinates 1460897..1461115 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TPET_RS07515 1457168..1458559 - 1392 WP_004083362.1 radical SAM protein -
TPET_RS09465 1458661..1458756 - 96 WP_010865309.1 Cys-rich RiPP peptide -
TPET_RS07520 1459193..1460800 + 1608 WP_011943917.1 helix-turn-helix domain-containing protein -
TPET_RS07525 1460897..1461115 + 219 WP_004083352.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
TPET_RS07530 1461112..1461342 + 231 WP_008195297.1 type II toxin-antitoxin system HicA family toxin Toxin
TPET_RS07535 1461365..1461577 + 213 WP_004079908.1 hypothetical protein -
TPET_RS09345 1461567..1461716 + 150 WP_081434644.1 type II toxin-antitoxin system HicA family toxin -
TPET_RS09350 1461787..1462188 - 402 Protein_1466 ABC transporter ATP-binding protein -
TPET_RS07545 1462252..1463022 - 771 WP_011943918.1 ABC transporter permease -
TPET_RS07550 1463026..1463460 - 435 WP_004079914.1 ABC transporter permease -
TPET_RS07555 1463678..1464484 - 807 WP_004079915.1 ABC transporter permease -
TPET_RS07560 1464478..1465239 - 762 WP_004079916.1 ABC transporter permease -
TPET_RS07565 1465190..1465966 - 777 WP_004079917.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1441437..1468142 26705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-64)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-57)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8881.54 Da        Isoelectric Point: 11.0394

>T22108 WP_008195297.1 NC_009486:1461112-1461342 [Thermotoga petrophila RKU-1]
MSYLPIVDPKTMEKVLLKLGFQRVRQKGSHVFYRHSNGRYTTIPFHARALPKSLIRKIIREAGISVEEFKKVLENL

Download         Length: 231 bp

>T22108 NC_009486:1461112-1461342 [Thermotoga petrophila RKU-1]
TTGAGTTATCTTCCAATAGTTGATCCAAAAACTATGGAAAAGGTTTTACTGAAACTTGGATTTCAACGTGTTCGCCAAAA
AGGAAGTCATGTGTTCTACAGGCACAGCAATGGCAGATATACGACCATCCCATTTCATGCAAGAGCCTTGCCCAAATCAC
TTATAAGAAAAATCATCCGTGAAGCGGGTATATCAGTGGAGGAATTCAAGAAAGTACTTGAGAATCTGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8183.29 Da        Isoelectric Point: 4.0887

>AT22108 WP_004083352.1 NC_009486:1460897-1461115 [Thermotoga petrophila RKU-1]
VRKIFTAIIEYDPETKQYVGMVPDVPGVHTVGSSLEEVRRNLKEVLELVLEEAGDEINHQEFVALEMIEVET

Download         Length: 219 bp

>AT22108 NC_009486:1460897-1461115 [Thermotoga petrophila RKU-1]
GTGCGCAAAATTTTCACAGCTATCATTGAATACGATCCTGAAACAAAGCAATATGTTGGAATGGTTCCGGACGTTCCGGG
TGTGCATACTGTAGGTAGTTCCTTAGAAGAAGTGAGAAGGAATTTAAAAGAGGTGCTTGAACTCGTATTGGAGGAAGCAG
GAGATGAAATAAATCACCAGGAATTCGTGGCTCTTGAGATGATAGAGGTGGAAACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B5L026

Antitoxin

Source ID Structure
AlphaFold DB A0A0A6N0B1

References