Detailed information of TA system TA221079

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3478142..3478762
• Replicon: chromosome
• Accession: NZ_CP085696
• Organism: Salmonella enterica subsp. enterica serovar Saintpaul strain S25

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: LJN58_RS17230
• Protein ID: WP_001280991.1
• Coordinates: 3478544..3478762 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: LJN58_RS17225
• Protein ID: WP_000344807.1
• Coordinates: 3478142..3478516 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJN58_RS17215 (3473281)	3473281..3474474	+	1194	WP_001039200.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
LJN58_RS17220 (3474497)	3474497..3477646	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
LJN58_RS17225 (3478142)	3478142..3478516	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
LJN58_RS17230 (3478544)	3478544..3478762	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
LJN58_RS17235 (3478941)	3478941..3479492	+	552	WP_001278792.1	maltose O-acetyltransferase	-
LJN58_RS17240 (3479609)	3479609..3480079	+	471	WP_000136181.1	YlaC family protein	-
LJN58_RS17245 (3480135)	3480135..3480275	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
LJN58_RS17250 (3480281)	3480281..3480541	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
LJN58_RS17255 (3480766)	3480766..3482316	+	1551	WP_000213139.1	EAL domain-containing protein	-
LJN58_RS17265 (3482547)	3482547..3482936	+	390	WP_000961285.1	MGMT family protein	-
LJN58_RS17270 (3482969)	3482969..3483538	-	570	WP_000779803.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T221079 WP_001280991.1 NZ_CP085696:3478544-3478762 [Salmonella enterica subsp. enterica serovar Saintpaul]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T221079 NZ_CP117340:824345-824758 [Salmonella enterica subsp. enterica serovar Dublin]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGTCAACACTGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT221079 WP_000344807.1 NZ_CP085696:3478142-3478516 [Salmonella enterica subsp. enterica serovar Saintpaul]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT221079 NZ_CP117340:824098-824364 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0