Detailed information of TA system TA221078

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 2378241..2378763
• Replicon: chromosome
• Accession: NZ_CP085696
• Organism: Salmonella enterica subsp. enterica serovar Saintpaul strain S25

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: B5F5Y5
• Locus tag: LJN58_RS11615
• Protein ID: WP_000221343.1
• Coordinates: 2378479..2378763 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: LJN58_RS11610
• Protein ID: WP_000885424.1
• Coordinates: 2378241..2378489 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJN58_RS11575 (2374272)	2374272..2374718	+	447	WP_000527682.1	helix-turn-helix transcriptional regulator	-
LJN58_RS11580 (2374818)	2374818..2375240	+	423	WP_000089313.1	hypothetical protein	-
LJN58_RS11585 (2375352)	2375352..2375819	+	468	WP_000218697.1	hypothetical protein	-
LJN58_RS11590 (2375865)	2375865..2376236	+	372	WP_000795853.1	hypothetical protein	-
LJN58_RS11595 (2376411)	2376411..2377125	+	715	Protein_2268	helix-turn-helix domain-containing protein	-
LJN58_RS11600 (2377181)	2377181..2377840	-	660	Protein_2269	hypothetical protein	-
LJN58_RS11605 (2377874)	2377874..2378089	-	216	WP_000206207.1	hypothetical protein	-
LJN58_RS11610 (2378241)	2378241..2378489	+	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LJN58_RS11615 (2378479)	2378479..2378763	+	285	WP_000221343.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LJN58_RS11620 (2378934)	2378934..2379323	+	390	WP_000194089.1	RidA family protein	-
LJN58_RS11625 (2379375)	2379375..2380454	-	1080	WP_023180968.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
LJN58_RS11630 (2380647)	2380647..2381135	-	489	WP_001293638.1	MarR family winged helix-turn-helix transcriptional regulator	-
LJN58_RS11635 (2381180)	2381180..2382688	+	1509	WP_000199411.1	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11075.85 Da
• Isoelectric Point: 10.6500

>T221078 WP_000221343.1 NZ_CP085696:2378479-2378763 [Salmonella enterica subsp. enterica serovar Saintpaul]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Nucleotide

• Length: 285 bp

>T221078 NZ_CP117340:358248-358523 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT221078 WP_000885424.1 NZ_CP085696:2378241-2378489 [Salmonella enterica subsp. enterica serovar Saintpaul]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT221078 NZ_CP117340:357985-358245 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Structures

Toxin

• AlphaFold DB: A0A5H5JSW4

Antitoxin

• AlphaFold DB: A0A5I0WPN5