Detailed information of TA system TA221063

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4375258..4376834
• Replicon: chromosome
• Accession: NZ_CP085688
• Organism: Providencia rettgeri strain 06-1619

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LHK11_RS20070
• Protein ID: WP_140172675.1
• Coordinates: 4375258..4376577 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LHK11_RS20075
• Protein ID: WP_140172676.1
• Coordinates: 4376577..4376834 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LHK11_RS20060 (LHK11_20060)	4371195..4374242	-	3048	WP_282550878.1	formate dehydrogenase-N subunit alpha	-
LHK11_RS20065 (LHK11_20065)	4374417..4375247	+	831	WP_036959175.1	formate dehydrogenase accessory sulfurtransferase FdhD	-
LHK11_RS20070 (LHK11_20070)	4375258..4376577	-	1320	WP_140172675.1	type II toxin-antitoxin system HipA family toxin	Toxin
LHK11_RS20075 (LHK11_20075)	4376577..4376834	-	258	WP_140172676.1	helix-turn-helix domain-containing protein	Antitoxin
LHK11_RS20080 (LHK11_20080)	4377157..4378521	-	1365	WP_004906223.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
LHK11_RS20085 (LHK11_20085)	4378623..4380272	-	1650	WP_004906225.1	membrane protein insertase YidC	-
LHK11_RS20090 (LHK11_20090)	4380275..4380535	-	261	WP_036959180.1	membrane protein insertion efficiency factor YidD	-
LHK11_RS20095 (LHK11_20095)	4380499..4380858	-	360	WP_004906229.1	ribonuclease P protein component	-
LHK11_RS20100 (LHK11_20100)	4380880..4381023	-	144	WP_004906236.1	50S ribosomal protein L34	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 50013.00 Da
• Isoelectric Point: 6.5676

>T221063 WP_140172675.1 NZ_CP085688:c4376577-4375258 [Providencia rettgeri]
MATLHVYMNGYLVGDLIRSSTGAHQFTYNSHWLETSGARPISLSMPLRHQEYRGDEVYNFFDNLLPDNIEIRNRIVSRYQ
ADSNQPFDLLSKIGQDSVGALQLILDGQRVSNIRKIEYKPLSNKQLEKILTGYKANAPLGMIEDEDDFRISLAGAQEKTA
LLYLDGHWCLPQNATPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKEFGLDVPYSFILNVGEIKALAVERFDRK
YSSDSSWIMRLPQEDFCQTLNISPARKYQNHGGPGISEIMNYLLGSINAEKDRYQFMKSQVLFWLLAATDGHAKNFSLFI
EPEGRYQLTPFYDILSMYPSYGGRGINPRDAKLAMGLKGTRGMKYNIEQIFPRHFFSTAKAVGFDRAEMEKILIEFGEQM
ESVIKKVREQLPTDFPEHIADSILSGLHHKAARLNKGWD

Nucleotide

• Length: 1320 bp

>T221063 NZ_CP117338:838557-838970 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9658.94 Da
• Isoelectric Point: 9.6898

>AT221063 WP_140172676.1 NZ_CP085688:c4376834-4376577 [Providencia rettgeri]
MKVTNTRQLSAYMKDVREMKKLSQSKVASKVGIRQDTVSSFELSPDSTKLETFFKILSALNLELDIKPRNESGSSNSDSG
WKEEW

Nucleotide

• Length: 258 bp

>AT221063 NZ_CP117338:838310-838576 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA