Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 4248331..4248914 Replicon chromosome
Accession NZ_CP085688
Organism Providencia rettgeri strain 06-1619

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LHK11_RS19420 Protein ID WP_140172875.1
Coordinates 4248612..4248914 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LHK11_RS19415 Protein ID WP_004265229.1
Coordinates 4248331..4248615 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHK11_RS19390 (LHK11_19390) 4243491..4244468 - 978 WP_004265237.1 6-phosphofructokinase -
LHK11_RS19395 (LHK11_19395) 4244875..4245819 - 945 WP_102140623.1 phosphatidate cytidylyltransferase -
LHK11_RS19400 (LHK11_19400) 4245816..4246457 - 642 WP_140172874.1 lysophospholipid acyltransferase family protein -
LHK11_RS19405 (LHK11_19405) 4246695..4247447 - 753 WP_004907010.1 M48 family metallopeptidase -
LHK11_RS19410 (LHK11_19410) 4247667..4248248 - 582 WP_094961882.1 HutD family protein -
LHK11_RS19415 (LHK11_19415) 4248331..4248615 - 285 WP_004265229.1 putative addiction module antidote protein Antitoxin
LHK11_RS19420 (LHK11_19420) 4248612..4248914 - 303 WP_140172875.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LHK11_RS19425 (LHK11_19425) 4249222..4249992 + 771 WP_094961881.1 hypothetical protein -
LHK11_RS19430 (LHK11_19430) 4250022..4250240 - 219 WP_094961880.1 ogr/Delta-like zinc finger family protein -
LHK11_RS19435 (LHK11_19435) 4250312..4251409 - 1098 WP_125893516.1 phage late control D family protein -
LHK11_RS19440 (LHK11_19440) 4251406..4251852 - 447 WP_102140831.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4248331..4281998 33667


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11463.39 Da        Isoelectric Point: 9.8470

>T221062 WP_140172875.1 NZ_CP085688:c4248914-4248612 [Providencia rettgeri]
MITVLTTECFDSWIKNLRDIRAKTKILMRIRWLKNGNYGDVQPIGDGFSELRVHEGQGYRVYLKQKNNVIVILLCGGTKA
TQQKDIHKAKLLFGEVEGEL

Download         Length: 303 bp

>T221062 NZ_CP117338:365058-365333 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10454.13 Da        Isoelectric Point: 4.5983

>AT221062 WP_004265229.1 NZ_CP085688:c4248615-4248331 [Providencia rettgeri]
MNTKLKEFDIAEYLNSEEEIQMYLNEILEEGDPSLVLAALGDIAKARNMSQLAKEVGMSREGLYKALSGQGNPTFMTIIK
IVNSLGLKLQFKSI

Download         Length: 285 bp

>AT221062 NZ_CP117338:364795-365055 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References