Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 3993147..3993732 Replicon chromosome
Accession NZ_CP085688
Organism Providencia rettgeri strain 06-1619

Toxin (Protein)


Gene name relE Uniprot ID D4C3N9
Locus tag LHK11_RS18150 Protein ID WP_004905874.1
Coordinates 3993147..3993464 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4C3P0
Locus tag LHK11_RS18155 Protein ID WP_004905876.1
Coordinates 3993445..3993732 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHK11_RS18120 (LHK11_18120) 3988850..3989101 - 252 WP_140171816.1 DUF1471 domain-containing protein -
LHK11_RS18125 (LHK11_18125) 3989372..3989710 + 339 WP_140171817.1 GIY-YIG nuclease family protein -
LHK11_RS18130 (LHK11_18130) 3989683..3990186 - 504 WP_112308100.1 N-acetyltransferase -
LHK11_RS18135 (LHK11_18135) 3990180..3990704 - 525 WP_140171818.1 SCP2 domain-containing protein -
LHK11_RS18140 (LHK11_18140) 3991219..3992214 + 996 WP_140171819.1 peptidase U32 family protein -
LHK11_RS18145 (LHK11_18145) 3992232..3993107 + 876 WP_140171820.1 U32 family peptidase -
LHK11_RS18150 (LHK11_18150) 3993147..3993464 - 318 WP_004905874.1 type II toxin-antitoxin system YafQ family toxin Toxin
LHK11_RS18155 (LHK11_18155) 3993445..3993732 - 288 WP_004905876.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LHK11_RS18160 (LHK11_18160) 3993863..3995017 - 1155 WP_140171821.1 ABC transporter permease -
LHK11_RS18165 (LHK11_18165) 3995017..3996162 - 1146 WP_004905879.1 ABC transporter permease -
LHK11_RS18170 (LHK11_18170) 3996174..3997145 - 972 WP_140171822.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(14-105)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12205.96 Da        Isoelectric Point: 9.7799

>T221061 WP_004905874.1 NZ_CP085688:c3993464-3993147 [Providencia rettgeri]
MTQKPSNKRAKQPRQVAYTPTFKKSWERYNRAGRRDMNAAVLVMEILFSQKIIPKEYLDHELEGHEWQGARELHIGGDFL
LVYRLSDKGNLITFVDIGSHSELFG

Download         Length: 318 bp

>T221061 NZ_CP117338:316721-317089 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10763.44 Da        Isoelectric Point: 5.8809

>AT221061 WP_004905876.1 NZ_CP085688:c3993732-3993445 [Providencia rettgeri]
MSTLLKTTDVRSRIDEQLKAEATSVLQDCGLTISAAIRLFLEQVVQEQRVPFEIKRKQPSLKTTLALKEAKAIEQHYDSI
NEMMVELSKVDSEAK

Download         Length: 288 bp

>AT221061 NZ_CP117338:316503-316724 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4C3N9

Antitoxin

Source ID Structure
AlphaFold DB A0A345M0A6

References